AKAP14 - A-kinase anchoring protein 14 Gene
Also Known as AKAP28; PRKA14
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 158798
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Restricted expression toward testis (RPKM 10.2).
AKAP14 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NG_013218.1 [RefSeqGene] |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12475942 | GOA |
| enables protein kinase A regulatory subunit binding |
IPI
IPI: Inferred from physical interaction
|
12475942 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in axoneme |
IDA
IDA: Inferred from direct assay
|
12475942 | GOA |
| part of cAMP-dependent protein kinase complex |
IMP
IMP: Inferred from mutant phenotype
|
12475942 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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AKAP14 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2A | Homo sapiens | P13861-2 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2A | Homo sapiens | P13861-2 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | ROPN1 | Homo sapiens | Q9HAT0 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2B | Homo sapiens | P31323 | 33961781 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2B | Homo sapiens | P31323 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2B | Homo sapiens | P31323 | 28514442 | |
|
Intra
|
AKAP14 | Q86UN6 | PRKAR2B | Homo sapiens | P31323 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | DPY30 | Homo sapiens | Q9C005 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | DPY30 | Homo sapiens | Q9C005 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | DPY30 | Homo sapiens | Q9C005 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | ROPN1L | Homo sapiens | Q96C74 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | ROPN1L | Homo sapiens | Q96C74 | 32296183 | |
|
Intra
|
AKAP14 | Q86UN6 | ROPN1L | Homo sapiens | Q96C74 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
AKAP14 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83333 | AKAP14 Antibody (YA3078) | WB, ICC/IF, IP | Human, Mouse, Rat |