AKAP5 - A-kinase anchoring protein 5 Gene

Homo sapiens

Also known as H21; AKAP75; AKAP79

Gene ID: 9495 | Gene type: protein coding

About AKAP5

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,465,499-64,474,503 (from NCBI)

This gene has 2 transcripts (splice variants) and 105 orthologues. Biased expression in brain (RPKM 10.3), colon (RPKM 3.6) and 10 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the Phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

AKAP5 Products(1)

mRNA	Protein	Name
NM_004857.3	NP_004848.3	A-kinase anchor protein 5

AKAP5 Protein Structure

WSK

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 5

A kinase (PRKA) anchor protein 5

Related Diseases

Diseases

Alias

Fleck Retina, Familial Benign

FRFB	Familial Benign Flecked Retina
Familial Benign Fleck Retina

Retinitis Pigmentosa 18

RP18	Retinitis Pigmentosa-18
Retinitis Pigmentosa, Type 18

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00520	AKAP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKAP5	VGNC	VGNC:25786
Mus musculus	AKAP5	MGD	MGI:2685104
Macaca mulatta	AKAP5	VGNC	VGNC:84299
Rattus norvegicus	AKAP5	RGD	RGD:620829
Felis catus	AKAP5	VGNC	VGNC:59715
Canis familiaris	AKAP5	VGNC	VGNC:37758

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