AKAP5 - A-kinase anchoring protein 5 Gene

Also Known as H21; AKAP75; AKAP79

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9495

About AKAP5

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,465,499-64,474,503 (from NCBI)

This gene has 2 transcripts (splice variants) and 105 orthologues. Biased expression in brain (RPKM 10.3), colon (RPKM 3.6) and 10 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase Calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

AKAP5 Products (1)

mRNA	Protein	Name
NM_004857.3	NP_004848.3	A-kinase anchor protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	10939335	GOA
enables adenylate cyclase binding	IPI IPI: Inferred from physical interaction	17081159	GOA
enables calmodulin binding	EXP EXP: Inferred from Experiment	35697294	GOA
enables glutamate receptor binding	IDA IDA: Inferred from direct assay	10939335	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11287423	GOA
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	21502359	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	10939335	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10939335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17081159	GOA
involved in calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	33941685	GOA
involved in negative regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	20410303	GOA
involved in positive regulation of endosome to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	25589740	GOA
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	25589740	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22343722	GOA
involved in regulation of protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	17081159	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	22343722	GOA
located in membrane raft	IMP IMP: Inferred from mutant phenotype	21771783	GOA
located in postsynaptic recycling endosome	IDA IDA: Inferred from direct assay	25589740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP5 Protein Structure

WSK

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
A-kinase anchor protein 5	A kinase (PRKA) anchor protein 5

AKAP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKAP5	P24588	PPP3CA	Homo sapiens	Q08209-2	Validated Y2H	32296183
Intra	AKAP5	P24588	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	32296183
Intra	AKAP5	P24588	PPP3CA	Homo sapiens	Q08209-1	GMS	22343722
Intra	AKAP5	P24588	PPP3CA	Homo sapiens	Q08209-1	Light Scattering	22343722
Intra	AKAP5	P24588	PPP3CA	Homo sapiens	Q08209-1	X-Ray Diffraction	22343722
Intra	AKAP5	P24588	PRKAR2A	Homo sapiens	P13861	Filter Binding	16642035
Intra	AKAP5	P24588	PRKAR2A	Homo sapiens	P13861	GMS	22343722
Intra	AKAP5	P24588	PRKAR2A	Homo sapiens	P13861	Anti Tag CoIP	26496610
Intra	AKAP5	P24588	PRKAR2A	Homo sapiens	P13861	FRET	22343722
Intra	AKAP5	P24588	PRKAR2B	Homo sapiens	P31323	Validated Y2H	32296183
Cross	AKAP5	P24588	Kcnj2	Mus musculus	P35561	Pull Down	11287423
Intra	AKAP5	P24588	RXFP1	Homo sapiens	Q9HBX9	Pull Down	20664520
Intra	AKAP5	P24588	ROPN1L	Homo sapiens	Q96C74	Validated Y2H	32296183
Intra	AKAP5	P24588	ROPN1L	Homo sapiens	Q96C74	Y2H Prey Pooling	32296183
Intra	AKAP5	P24588	ROPN1L	Homo sapiens	Q96C74	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fleck Retina, Familial Benign	FRFB Familial Benign Flecked Retina Familial Benign Fleck Retina
Retinitis Pigmentosa 18	RP18 Retinitis Pigmentosa-18 Retinitis Pigmentosa, Type 18
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00520	AKAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21476	Akap5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27994	Akap5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKAP5	VGNC	VGNC:25786
Mus musculus	AKAP5	MGD	MGI:2685104
Macaca mulatta	AKAP5	VGNC	VGNC:84299
Rattus norvegicus	AKAP5	RGD	RGD:620829
Felis catus	AKAP5	VGNC	VGNC:59715
Canis familiaris	AKAP5	VGNC	VGNC:37758
Others	AKAP5	NCBI