DRG2 - developmentally regulated GTP binding protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1819

About DRG2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,087,948-18,107,969 (from NCBI)

This gene has 21 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

DRG2 Products (2)

mRNA Protein Name
NM_001330144.2 NP_001317073.1 developmentally-regulated GTP-binding protein 2 isoform 2
NM_001388.5 NP_001379.1 developmentally-regulated GTP-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
29915238 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
29915238 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
29915238 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29915238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRG2 Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (64 - 155)

TGS

TGS: TGS domain (291 - 363)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

developmentally-regulated GTP-binding protein 2

  • TRAFAC GTPase DRG2

DRG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
DRG2 P55039 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Anti Tag CoIP
33961781
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Validated Y2H
25416956
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Pooling
16189514
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Anti Tag CoIP
28514442
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Validated Y2H
32296183
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Array
32296183
Intra
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
32296183
Intra
DRG2 P55039 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
Intra
DRG2 P55039 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra
DRG2 P55039 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Volkmann Contracture

  • Ischemic Contracture

  • Volkmann'S Ischemic Contracture
Radial Neuropathy
Potocki-Lupski Syndrome

  • PTLS

  • Chromosome 17p11.2 Duplication Syndrome

  • 17p11.2 Microduplication Syndrome

  • Duplication 17p11.2 Syndrome

  • Trisomy 17p11.2

  • Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

  • 17p11.2 Duplication Syndrome

  • Dup(17)(P11.2p11.2)

  • Pls

  • Chromosome 17, Trisomy 17p11 2
Craniometaphyseal Dysplasia, Autosomal Dominant

  • Craniometaphyseal Dysplasia

  • CMDD

  • Cmdj

  • Cmd

  • Autosomal Dominant Craniometaphyseal Dysplasia

  • Craniometaphyseal Dysplasia, Jackson Type

  • Craniometaphyseal Dysplasia Jackson Type

  • Autosomal Recessive Craniometaphyseal Dysplasia

  • Cmdr

  • Dysplasia, Craniometaphyseal, Autosomal Dominant

  • Craniometaphyseal Dysplasia, Autosomal Recessive Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04010 DRG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DRG2 VGNC VGNC:28209
Felis catus DRG2 VGNC VGNC:61631
Canis familiaris DRG2 VGNC VGNC:40098
Rattus norvegicus DRG2 RGD RGD:1562380
Mus musculus DRG2 MGD MGI:1342307
Macaca mulatta DRG2 VGNC VGNC:71993
Others DRG2 NCBI