RPS6KA5 - ribosomal protein S6 kinase A5 Gene

Homo sapiens

Also known as MSK1; RLPK; MSPK1

Gene ID: 9252 | Gene type: protein coding

About RPS6KA5

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,847,861-91,060,641 (from NCBI)

This gene has 8 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RPS6KA5 Products(14)

mRNA	Protein	Name
NM_001322227.2	NP_001309156.1	ribosomal protein S6 kinase alpha-5 isoform c
NM_001322228.2	NP_001309157.1	ribosomal protein S6 kinase alpha-5 isoform d
NM_001322229.2	NP_001309158.1	ribosomal protein S6 kinase alpha-5 isoform e
NM_001322230.2	NP_001309159.1	ribosomal protein S6 kinase alpha-5 isoform f
NM_001322231.2	NP_001309160.1	ribosomal protein S6 kinase alpha-5 isoform g
NM_001322232.2	NP_001309161.1	ribosomal protein S6 kinase alpha-5 isoform h
NM_001322233.2	NP_001309162.1	ribosomal protein S6 kinase alpha-5 isoform i
NM_001322234.2	NP_001309163.1	ribosomal protein S6 kinase alpha-5 isoform j
NM_001322235.2	NP_001309164.1	ribosomal protein S6 kinase alpha-5 isoform k
NM_001322236.2	NP_001309165.1	ribosomal protein S6 kinase alpha-5 isoform l
NM_001322237.2	NP_001309166.1	ribosomal protein S6 kinase alpha-5 isoform k
NM_001322238.2	NP_001309167.1	ribosomal protein S6 kinase alpha-5 isoform m
NM_004755.4	NP_004746.2	ribosomal protein S6 kinase alpha-5 isoform a
NM_182398.3	NP_872198.1	ribosomal protein S6 kinase alpha-5 isoform b

RPS6KA5 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
802 a.a.

Protein Preferred Names

Protein Names

ribosomal protein S6 kinase alpha-5

90 kDa ribosomal protein S6 kinase 5

Related Diseases

Diseases

Alias

Joubert Syndrome 28

JBTS28

Coffin-Lowry Syndrome

CLS	Coffin Syndrome 1
Coffin Syndrome	Intellectual Disability With Osteocartilaginous Abnormalities
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Mental Retardation With Osteocartilaginous Abnormalities	Coffin Lowry Syndrome

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12258	RPS6KA5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS6KA5	MGD	MGI:1920336
Bos taurus	RPS6KA5	VGNC	VGNC:34144
Rattus norvegicus	RPS6KA5	RGD	RGD:1308336
Felis catus	RPS6KA5	VGNC	VGNC:64758
Canis familiaris	RPS6KA5	VGNC	VGNC:45742
Macaca mulatta	RPS6KA5	VGNC	VGNC:76931
Others	RPS6KA5	NCBI

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