RPS6KA5 - ribosomal protein S6 kinase A5 Gene

Also Known as MSK1; RLPK; MSPK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9252

About RPS6KA5

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,847,861-91,060,641 (from NCBI)

This gene has 8 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RPS6KA5 Products (14)

mRNA Protein Name
NM_001322227.2 NP_001309156.1 ribosomal protein S6 kinase alpha-5 isoform c
NM_001322228.2 NP_001309157.1 ribosomal protein S6 kinase alpha-5 isoform d
NM_001322229.2 NP_001309158.1 ribosomal protein S6 kinase alpha-5 isoform e
NM_001322230.2 NP_001309159.1 ribosomal protein S6 kinase alpha-5 isoform f
NM_001322231.2 NP_001309160.1 ribosomal protein S6 kinase alpha-5 isoform g
NM_001322232.2 NP_001309161.1 ribosomal protein S6 kinase alpha-5 isoform h
NM_001322233.2 NP_001309162.1 ribosomal protein S6 kinase alpha-5 isoform i
NM_001322234.2 NP_001309163.1 ribosomal protein S6 kinase alpha-5 isoform j
NM_001322235.2 NP_001309164.1 ribosomal protein S6 kinase alpha-5 isoform k
NM_001322236.2 NP_001309165.1 ribosomal protein S6 kinase alpha-5 isoform l
NM_001322237.2 NP_001309166.1 ribosomal protein S6 kinase alpha-5 isoform k
NM_001322238.2 NP_001309167.1 ribosomal protein S6 kinase alpha-5 isoform m
NM_004755.4 NP_004746.2 ribosomal protein S6 kinase alpha-5 isoform a
NM_182398.3 NP_872198.1 ribosomal protein S6 kinase alpha-5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9687510 GOA
enables histone H2AS1 kinase activity IDA
IDA: Inferred from direct assay
15010469 GOA
enables histone H3S10 kinase activity IMP
IMP: Inferred from mutant phenotype
12773393 GOA
enables histone H3S28 kinase activity IMP
IMP: Inferred from mutant phenotype
12773393 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9687510 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
9873047 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20018936 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9687510 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15010469 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12628924 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20018936 GOA
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
15010469 GOA
involved in post-translational protein modification IMP
IMP: Inferred from mutant phenotype
12773393 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9687510 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9687510 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12763138 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18511904 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9687510 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
12628924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA5 Protein Structure

Pkinase

Pkinase: Protein kinase domain (49 - 318)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (340 - 381)

Pkinase

Pkinase: Protein kinase domain (429 - 686)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-5

  • 90 kDa ribosomal protein S6 kinase 5

RPS6KA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS6KA5 O75582 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
RPS6KA5 O75582 CSNK2B Homo sapiens P67870
Y2H
21988832
Intra
RPS6KA5 O75582 CSNK2B Homo sapiens P67870
Pull Down
32707033
Intra
RPS6KA5 O75582 MAP3K20 Homo sapiens Q9NYL2
Pull Down
21988832
Intra
RPS6KA5 O75582 MAP3K20 Homo sapiens Q9NYL2
Confocal
21988832
Intra
RPS6KA5 O75582 MAPK14 Homo sapiens Q16539
Y2H Pooling
20936779
Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6KA5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80835 Phospho-MSK1 (Ser360) Antibody (YA173) WB, ICC/IF, IP Human, Mouse, Rat, Hamster
HY-P80835A Phospho-MSK1 (Ser360) Antibody (YA173)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat, Hamster
HY-P80836 Phospho-MSK1 (Ser376) Antibody (YA172) WB, IHC-P, IP Human, Rat
HY-P80836A Phospho-MSK1 (Ser376) Antibody (YA172)(PBS only) WB, IHC-P, IP Human, Rat
HY-P86551 Phospho-MSK1(Ser360) Antibody (YA6243) WB, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Joubert Syndrome 28

  • JBTS28
Coffin-Lowry Syndrome

  • CLS

  • Coffin Syndrome 1

  • Coffin Syndrome

  • Intellectual Disability With Osteocartilaginous Abnormalities

  • Dwarfism, Lean Spastic Type

  • Lean Spastic Dwarfism

  • Mental Retardation With Osteocartilaginous Abnormalities

  • Coffin Lowry Syndrome
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12258 RPS6KA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22026 Rps6ka5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28544 Rps6ka5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPS6KA5 MGD MGI:1920336
Bos taurus RPS6KA5 VGNC VGNC:34144
Rattus norvegicus RPS6KA5 RGD RGD:1308336
Felis catus RPS6KA5 VGNC VGNC:64758
Canis familiaris RPS6KA5 VGNC VGNC:45742
Macaca mulatta RPS6KA5 VGNC VGNC:76931
Others RPS6KA5 NCBI