MAP3K20 - mitogen-activated protein kinase kinase kinase 20 Gene

Also Known as pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51776

About MAP3K20

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,075,517-173,268,015 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues, 23 paralogues and is associated with 4 phenotypes. Broad expression in heart (RPKM 51.0), fat (RPKM 33.9) and 21 other tissues.

Summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

MAP3K20 Products (2)

mRNA	Protein	Name
NM_016653.3	NP_057737.2	mitogen-activated protein kinase kinase kinase 20 isoform 1
NM_133646.3	NP_598407.1	mitogen-activated protein kinase kinase kinase 20 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11836244	GOA
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11836244	GOA
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11836244	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11836244	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12761180	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	32610081	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	32289254	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32289254	GOA
enables small ribosomal subunit rRNA binding	IDA IDA: Inferred from direct assay	32289254	GOA
enables stalled ribosome sensor activity	IDA IDA: Inferred from direct assay	32289254	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	11836244	GOA
acts upstream of GCN2-mediated signaling	IDA IDA: Inferred from direct assay	32610081	GOA
involved in JNK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in MAPK cascade	IDA IDA: Inferred from direct assay	18331592	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	32289254	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	11836244	GOA
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	26755636	GOA
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	18331592	GOA
involved in limb development	IMP IMP: Inferred from mutant phenotype	26755636	GOA
involved in negative regulation of stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA
involved in negative regulation of translation in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	32610081	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10924358	GOA
involved in positive regulation of mitotic DNA damage checkpoint	IDA IDA: Inferred from direct assay	15342622	GOA
acts upstream of positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	32289254	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12220515	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11836244	GOA
acts upstream of positive effect pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	35857590	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	15684425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K20 Protein Structure

Pkinase_Tyr

SAM_1

0
200
400
600
800 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 20	HCCS-4

MAP3K20 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAP3K20	Q9NYL2	RPS6KA5	Homo sapiens	O75582	Y2H	21988832
Intra	MAP3K20	Q9NYL2	RPS6KA5	Homo sapiens	O75582	Anti Tag CoIP	21988832
Intra	MAP3K20	Q9NYL2	ZNF567	Homo sapiens	Q8N184	Y2H	21516116
Intra	MAP3K20	Q9NYL2	ZNF567	Homo sapiens	Q8N184	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Split-Foot Malformation With Mesoaxial Polydactyly	SFMMP Split-Foot Malformation-Mesoaxial Polydactyly Syndrome Split-Foot Malformation-Mesoaxial Polydactyly-Nail Abnormalities-Sensorineural Hearing Loss Syndrome
Myopathy, Centronuclear, 6, With Fiber-Type Disproportion	CNM6 Centronuclear Myopathy 6 With Fiber-Type Disproportion Myopathy, Centronuclear, Type 6, With Fiber-Type Disproportion
Split-Hand/Foot Malformation 1	Ectrodactyly Split Hand-Foot Malformation 1 SHFM1 Shfd1 Split-Hand Deformity Split-Hand/Foot Malformation 1 With Or Without Deafness Split-Hand/Foot Deformity 1 Ecd Split Hand/Foot Malformation Type 1 Split Hand Foot Deformity 1 Split-Hand/Foot Malformation
Congenital Fiber-Type Disproportion	Congenital Fiber Type Disproportion Cftdm Congenital Myopathy With Fiber Type Disproportion Cftd Congenital Fiber-Type Disproportion Myopathy Fiber-Type Disproportion Myopathy, Congenital Myopathy, Congenital With Fiber-Type Disproportion
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive	Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss SHFM1D Deafness, Congenital, With Split Hands And Feet Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss Congenital Deafness With Split Hands And Feet Split Hand-Split Foot-Deafness Syndrome Split Hand-Split Foot-Hearing Loss Syndrome Congenital Deafness And Split Hands And Feet Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss Split-Hand-Foot Malformation With Sensorineural Hearing Loss
Centronuclear Myopathy	Myopathy, Centronuclear Myotubular Myopathy Cnm Myopathy, Myotubular Congenital Structural Myopathy
Myopathy	Muscular Diseases Myopathies
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-RS08055	MAP3K20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP3K20	MGD	MGI:2443258
Rattus norvegicus	MAP3K20	RGD	RGD:1561394
Macaca mulatta	MAP3K20	VGNC	VGNC:99379
Canis familiaris	MAP3K20	VGNC	VGNC:53099
Others	MAP3K20	NCBI