PCGF5 - polycomb group ring finger 5 Gene

Homo sapiens

Also known as RNF159

Gene ID: 84333 | Gene type: protein coding

About PCGF5

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,156,219-91,284,337 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

PCGF5 Products(3)

mRNA	Protein	Name
NM_001256549.2	NP_001243478.1	polycomb group RING finger protein 5
NM_001257101.2	NP_001244030.1	polycomb group RING finger protein 5
NM_032373.5	NP_115749.2	polycomb group RING finger protein 5

PCGF5 Protein Structure

zf-C3HC4

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

polycomb group RING finger protein 5

RING finger protein 159

Related Diseases

Diseases

Alias

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10148	PCGF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PCGF5	VGNC	VGNC:44303
Macaca mulatta	PCGF5	VGNC	VGNC:106085
Rattus norvegicus	PCGF5	RGD	RGD:1583513
Mus musculus	PCGF5	MGD	MGI:1923505
Bos taurus	PCGF5	VGNC	VGNC:32628

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