RING1 - ring finger protein 1 Gene

Also Known as RNF1; RING1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6015

About RING1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,208,500-33,212,716 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 187 orthologues and 7 paralogues. Ubiquitous expression in endometrium (RPKM 22.9), ovary (RPKM 22.0) and 25 other tissues.

Summary

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

RING1 Products (1)

mRNA Protein Name
NM_002931.4 NP_002922.2 E3 ubiquitin-protein ligase RING1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15386022 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
16943429 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9199346 GOA
Cellular Component GO Annotation Evidence References Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
12167701 GOA
part of PcG protein complex IDA
IDA: Inferred from direct assay
16943429 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9199346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RING1 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (48 - 87)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RING1

  • RING-type E3 ubiquitin transferase RING1

RING1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
RING1 Q06587 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
RING1 Q06587 PCGF6 Homo sapiens Q9BYE7
TAP
27705803
Intra
RING1 Q06587 PCGF6 Homo sapiens Q9BYE7
TAP
24981860
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Validated Y2H
32296183
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Y2H Array
32296183
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Validated Y2H
32296183
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8-2
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 ZIM3 Homo sapiens Q96PE6
Validated Y2H
32296183
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
TAP
27705803
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
TAP
24981860
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
Anti Tag CoIP
22493164
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
Y2H Array
32296183
Intra
RING1 Q06587 PCGF2 Homo sapiens P35227
Anti Tag CoIP
19636380
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
Anti Tag CoIP
22493164
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
Y2H Array
22493164
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
TAP
24981860
Intra
RING1 Q06587 PCGF3 Homo sapiens Q3KNV8
TAP
27705803
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Array
22493164
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Bait CoIP
15386022
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Bait CoIP
22897849
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Array
32296183
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
TAP
24981860
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
TAP
27705803
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Y2H Prey Pooling
25416956
Intra
RING1 Q06587 BMI1 Homo sapiens P35226
Anti Tag CoIP
22493164
Intra
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
TAP
27705803
Intra
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Validated Y2H
32296183
Intra
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
TAP
24981860
Intra
RING1 Q06587 PCGF5 Homo sapiens Q86SE9
Y2H Array
32296183
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57
Validated Y2H
25416956
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57
TAP
24981860
Intra
RING1 Q06587 YAF2 Homo sapiens Q8IY57
TAP
27705803
Intra
RING1 Q06587 USP7 Homo sapiens Q93009
Pull Down
20601937
Intra
RING1 Q06587 USP7 Homo sapiens Q93009
Anti Tag CoIP
20601937
Intra
RING1 Q06587 USP11 Homo sapiens P51784
Anti Tag CoIP
20601937
Intra
RING1 Q06587 USP11 Homo sapiens P51784
Pull Down
20601937
Intra
RING1 Q06587 TP53 Homo sapiens P04637
IF
29187402
Intra
RING1 Q06587 TP53 Homo sapiens P04637
Anti Bait CoIP
29187402
Intra
RING1 Q06587 TP53 Homo sapiens P04637
Ubiquitinase Assay
29187402
Intra
RING1 Q06587 TP53 Homo sapiens P04637
Anti Tag CoIP
29187402
Intra
RING1 Q06587 CBX7 Homo sapiens O95931
TAP
27705803
Intra
RING1 Q06587 CBX7 Homo sapiens O95931
Anti Tag CoIP
21282530
Intra
RING1 Q06587 CBX6 Homo sapiens O95503
TAP
27705803
Intra
RING1 Q06587 CBX6 Homo sapiens O95503
TAP
24981860
Intra
RING1 Q06587 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
RING1 Q06587 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
RING1 Q06587 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
TAP
24981860
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
TAP
27705803
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
21282530
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
25416956
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
32296183
Intra
RING1 Q06587 CBX8 Homo sapiens Q9HC52
Y2H Array
32296183
Intra
RING1 Q06587 RNF2 Homo sapiens Q99496
Anti Bait CoIP
15386022
Intra
RING1 Q06587 RNF2 Homo sapiens Q99496
Pull Down
16943429
Intra
RING1 Q06587 RNF2 Homo sapiens Q99496
Anti Tag CoIP
35271311
Intra
RING1 Q06587 RNF2 Homo sapiens Q99496
TAP
24981860
Intra
RING1 Q06587 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Intra
RING1 Q06587 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19549727
Intra
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
Pull Down
16943429
Intra
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
TAP
24981860
Intra
RING1 Q06587 PCGF1 Homo sapiens Q9BSM1
TAP
27705803
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
TAP
24981860
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
Validated Y2H
25416956
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
TAP
27705803
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
Validated Y2H
32296183
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
Y2H Array
25416956
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
MAPPIT
25416956
Intra
RING1 Q06587 RYBP Homo sapiens Q8N488
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

RING1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82606 RING1 Antibody (YA2351) WB, IHC-P, ICC/IF Human
HY-P84499 RING1 Antibody (YA4196) WB, IHC-P, FC, ELISA Human
HY-P84499A RING1 Antibody (YA4196)(PBS only) WB, IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Granulomatosis With Polyangiitis

  • GPA

  • Wegener Granulomatosis

  • Wegener Granulomatosis, Formerly

  • Midline Granulomatosis

  • Wg, Formerly

  • Necrotizing Respiratory Granulomatosis

  • Wg

  • Wegeners Granulomatosis

  • Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Juvenile-Onset Parkinson'S Disease

  • Juvenile-Onset Parkinson Disease
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N16025 DOPE-PEG(2000) Amine ammonium / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139514 RB-3 Inhibitor 99.14% Unkown
HY-160924 MS147 Degrader 98.31% Unkown
HY-170823 PRC1-IN-1 Inhibitor 97.30% Unkown
HY-158239 MS181 Inhibitor 98.36% Unkown
HY-103291 Sar-[D-Phe8]-des-Arg9-Bradykinin Agonist 99.96% Unkown
HY-124467 Difludiazepam Ligand 98.9% Unkown
HY-RS11985 RING1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116918 N,N-Diphenylacetamide 99.40% Unkown
HY-W507009 L-Arginyl-L-alanine 99.75% Unkown
HY-129665 GS-389 Inhibitor / Unkown
HY-138140 Desertomycin A / Unkown
HY-160562 PROTAC ERα Degrader-7 Degrader / Unkown
HY-N19716 Austamide / Unkown
HY-P3228 JKC 302 Antagonist / Unkown
HY-W160625 3,5-Dimethyl-2-cyclohexen-1-one 99.75% Unkown
HY-183634 BMI1/RING1B ligand-1 / Unkown
HY-N15186 Gymnoascolide A / Unkown
HY-RS18405 Ring1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24886 Ring1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RING1 VGNC VGNC:33977
Macaca mulatta RING1 VGNC VGNC:83457
Rattus norvegicus RING1 RGD RGD:3576
Mus musculus RING1 MGD MGI:1101770
Canis familiaris RING1 VGNC VGNC:45589
Others RING1 NCBI