2. Gene
  3. PCGF6 - polycomb group ring finger 6 Gene

PCGF6 - polycomb group ring finger 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MBLR; RNF134

Gene ID: 84108 | Gene type: protein coding

About PCGF6

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,302,796-103,351,140 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 6.3), fat (RPKM 4.5) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PCGF6 Products(2)

mRNA Protein Name
NM_001011663.2 NP_001011663.1 polycomb group RING finger protein 6 isoform a
NM_032154.4 NP_115530.2 polycomb group RING finger protein 6 isoform b

PCGF6 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (134 - 172)

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  • 350 a.a.
Protein Preferred Names Protein Names

polycomb group RING finger protein 6

Mel18 and Bmi1-like RING finger protein

Related Diseases

Diseases Alias
Medulloblastoma Non-Wnt/Non-Shh
Medulloblastoma Shh Activated And Tp53 Wild-Type

Medulloblastoma Shh-Activated Tp53-Wildtype
Medulloblastoma Wnt Activated
Medulloblastoma Shh Activated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10149 PCGF6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCGF6 RGD RGD:1306904
Bos taurus PCGF6 VGNC VGNC:97296
Mus musculus PCGF6 MGD MGI:1918291
Canis familiaris PCGF6 VGNC VGNC:44304
Macaca mulatta PCGF6 VGNC VGNC:75662
Felis catus PCGF6 VGNC VGNC:64068