2. Gene
  3. USP11 - ubiquitin specific peptidase 11 Gene

USP11 - ubiquitin specific peptidase 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UHX1

Gene ID: 8237 | Gene type: protein coding

About USP11

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,233,009-47,248,328 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues and 71 paralogues. Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating Enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

USP11 Products(1)

mRNA Protein Name
NM_001371072.1 NP_001358001.1 ubiquitin carboxyl-terminal hydrolase 11

USP11 Protein Structure

DUSP

DUSP: DUSP domain (99 - 184)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (207 - 284)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (308 - 927)

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  • 963 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 11

deubiquitinating enzyme 11

Related Diseases

Diseases Alias
Bronchiectasis

Polynesian Bronchiectasis

Kartagener Syndrome

Bronchiectasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15522 USP11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP11 RGD RGD:1303052
Felis catus USP11 VGNC VGNC:66865
Bos taurus USP11 VGNC VGNC:36711
Canis familiaris USP11 VGNC VGNC:54609
Mus musculus USP11 MGD MGI:2384312
Macaca mulatta USP11 VGNC VGNC:78734
Others USP11 NCBI