DECR2 - 2,4-dienoyl-CoA reductase 2 Gene

Also Known as PDCR; SDR17C1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26063

About DECR2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:401,885-412,482 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 200 orthologues and 1 paralogue. Broad expression in kidney (RPKM 18.7), liver (RPKM 15.2) and 25 other tissues.

Summary

Enables 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

DECR2 Products (1)

mRNA Protein Name
NM_020664.4 NP_065715.1 peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

DECR2 Protein Structure

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (38 - 271)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

  • 2,4-dienoyl-CoA reductase 2, peroxisomal

DECR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DECR2 Q9NUI1 WDTC1 Homo sapiens Q8N5D0
Anti Tag CoIP
33961781
Intra
DECR2 Q9NUI1 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
DECR2 Q9NUI1 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Inflammation Of Lacrimal Passage
Dacryocystitis

  • Nasolacrimal Sac Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03668 DECR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20009 Decr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26512 Decr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DECR2 MGD MGI:1347059
Macaca mulatta DECR2 VGNC VGNC:71767
Felis catus DECR2 VGNC VGNC:61423
Bos taurus DECR2 VGNC VGNC:27983
Rattus norvegicus DECR2 RGD RGD:71002
Canis familiaris DECR2 VGNC VGNC:54016
Others DECR2 NCBI