1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. RB-3

RB-3 

Cat. No.: HY-139514
Handling Instructions

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.

For research use only. We do not sell to patients.

RB-3 Chemical Structure

RB-3 Chemical Structure

CAS No. : 2396639-11-3

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Description

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].

IC50 & Target

Kd: 2.8 μM (RING1B-BMI1f)[1].

In Vitro

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1].
RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1].
RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1].
RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: TEX cells.
Concentration: 6, 12, 25 μM.
Incubation Time: 8d.
Result: Dose-dependently increased C/EBPα-p42 protein levels.
Molecular Weight

417.89

Formula

C₂₄H₂₀ClN₃O₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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RB-3
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