PCGF2 - polycomb group ring finger 2 Gene

Homo sapiens

Also known as TPFS; MEL-18; RNF110; ZNF144

Gene ID: 7703 | Gene type: protein coding

About PCGF2

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,733,898-38,749,792 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 180 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

PCGF2 Products(3)

mRNA	Protein	Name
NM_001369614.1	NP_001356543.1	polycomb group RING finger protein 2
NM_001369615.1	NP_001356544.1	polycomb group RING finger protein 2
NM_007144.3	NP_009075.1	polycomb group RING finger protein 2

PCGF2 Protein Structure

zf-C3HC4

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

polycomb group RING finger protein 2

DNA-binding protein Mel-18

Related Diseases

Diseases

Alias

Turnpenny-Fry Syndrome

TPFS	Neurocardioskeletal Syndrome

Pontocerebellar Hypoplasia, Type 13

PCH13	Pontocerebellar Hypoplasia Type 13
Pontocerebellar Hypoplasia 13	Doid:0112332
Hypoplasia, Pontocerebellar, Type 13

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10146	PCGF2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCGF2	RGD	RGD:1305097
Macaca mulatta	PCGF2	VGNC	VGNC:104640
Felis catus	PCGF2	VGNC	VGNC:64066
Mus musculus	PCGF2	MGD	MGI:99161
Canis familiaris	PCGF2	VGNC	VGNC:44301
Bos taurus	PCGF2	VGNC	VGNC:32627

Name
Email *

	Sorry, but the email address you supplied was invalid.