KAT8 - lysine acetyltransferase 8 Gene

Also Known as MOF; hMOF; MYST1; LIGOWS; ZC2HC8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84148

About KAT8

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,117,664-31,131,393 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 17.1), testis (RPKM 11.9) and 25 other tissues.

Summary

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

KAT8 Products (2)

mRNA	Protein	Name
NM_032188.3	NP_115564.2	histone acetyltransferase KAT8 isoform 1
NM_182958.4	NP_892003.2	histone acetyltransferase KAT8 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	11965546	GOA
enables histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	27382063	GOA
contributes to histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	20018852	GOA
enables histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	21217699	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	20018852	GOA
enables histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	27768893	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	20018852	GOA
enables histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	27768893	GOA
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	17189187	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11742995	GOA
enables protein propionyltransferase activity	IDA IDA: Inferred from direct assay	29321206	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11742995	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in myeloid cell differentiation	IDA IDA: Inferred from direct assay	11742995	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11742995	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	27292636	GOA
involved in neurogenesis	IDA IDA: Inferred from direct assay	31794431	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11742995	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	33657400	GOA
acts upstream of or within regulation of autophagy	IDA IDA: Inferred from direct assay	23863932	GOA
involved in regulation of mRNA processing	IDA IDA: Inferred from direct assay	37369679	GOA
involved in regulation of mitochondrial transcription	IDA IDA: Inferred from direct assay	27768893	GOA
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	15960975	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
part of MSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
part of NSL complex	IDA IDA: Inferred from direct assay	19854137	GOA
is active in chromosome	IDA IDA: Inferred from direct assay	33657400	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	27768893	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28991411	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11742995	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT8 Protein Structure

Tudor-knot

MOZ_SAS

0
100
200
300
400
458 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase KAT8	K(lysine) acetyltransferase 8

KAT8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KAT8	Q9H7Z6	TP53	Homo sapiens	P04637	Anti Tag CoIP	16601686
Intra	KAT8	Q9H7Z6	KMT2A	Homo sapiens	Q03164	Anti Bait CoIP	15960975
Intra	KAT8	Q9H7Z6	KMT2A	Homo sapiens	Q03164	Pull Down	15960975
Intra	KAT8	Q9H7Z6	RNF2	Homo sapiens	Q99496	Anti Bait CoIP	15960975
Cross	KAT8	Q9H7Z6	HHF1	Saccharomyces cerevisiae	P02309	Enzymatic Study	22020126

Cross: Cross-species interaction Intra: Intraspecies interaction

KAT8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82485	MYST1 Antibody (YA2230)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P84803	MYST1 Antibody (YA4500)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P84803A	MYST1 Antibody (YA4500)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85282	MYST1 Antibody (YA4974)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Li-Ghorbani-Weisz-Hubshman Syndrome	LIGOWS Li-Ghorgani-Weisz-Hubshman Syndrome
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Koolen-De Vries Syndrome	KDVS 17q21.31 Microdeletion Syndrome Microdeletion 17q21.31 Syndrome Chromosome 17q21.31 Deletion Syndrome Koolen De Vries Syndrome Kansl1-Related Intellectual Disability Syndrome Chromosome 17q21.31 Microdeletion Syndrome Monosomy 17q21.31 17q21.31 Deletion Syndrome Koolen Syndrome Del(17)(Q21.31)
Capgras Syndrome	Capgras Delusion Theory
Haverhill Fever	Streptobacillosis Streptobacillary Rat-Bite Fever Streptobacillary Fever Rat-Bite Fever Due To Streptobacillus Moniliformis Erythema Arthriticum Epidemicum Epidemic Arthritic Erythema
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15887	MG 149		99.60%	Unkown
HY-W015239	KAT8-IN-1		99.61%	Unkown
HY-149302	MC4033		98.26%	Unkown
HY-153604	MC4171	Inhibitor	99.37%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-RS17587	Kat8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07084	KAT8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24047	Kat8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W614583	4-Aminonaphthalen-1-yl acetate	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KAT8	VGNC	VGNC:63027
Rattus norvegicus	KAT8	RGD	RGD:1311512
Mus musculus	KAT8	MGD	MGI:1915023
Macaca mulatta	KAT8	VGNC	VGNC:99520
Bos taurus	KAT8	VGNC	VGNC:30404
Canis familiaris	KAT8	VGNC	VGNC:42215
Others	KAT8	NCBI