2. Epigenetics
  3. Histone Acetyltransferase
  4. MC4171

MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer.

For research use only. We do not sell to patients.

MC4171 Chemical Structure

MC4171 Chemical Structure

Size Price Stock Quantity
5 mg USD 165 In-stock
10 mg USD 266 In-stock
25 mg USD 530 In-stock
50 mg USD 850 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

MC4171 Related Antibodies

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Description

MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer[1].

IC50 & Target

KAT8[1].
Molecular Weight

357.36

Formula

C21H15N3O3
Appearance

Solid

Color

Brown to orange

SMILES

O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3)/C(C2=O)=C/C4=CC=CN4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (69.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7983 mL 13.9915 mL 27.9830 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7983 mL 13.9915 mL 27.9830 mL 69.9575 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL 13.9915 mL
10 mM 0.2798 mL 1.3991 mL 2.7983 mL 6.9957 mL
15 mM 0.1866 mL 0.9328 mL 1.8655 mL 4.6638 mL
20 mM 0.1399 mL 0.6996 mL 1.3991 mL 3.4979 mL
25 mM 0.1119 mL 0.5597 mL 1.1193 mL 2.7983 mL
30 mM 0.0933 mL 0.4664 mL 0.9328 mL 2.3319 mL
40 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7489 mL
50 mM 0.0560 mL 0.2798 mL 0.5597 mL 1.3991 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1660 mL
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MC4171 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC4171MC 4171MC-4171Histone AcetyltransferaseHATsHATNSCLCAMLcancertumorHT29 cellsantiproliferativeInhibitorinhibitorinhibit

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