1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU 0364439

VU 0364439 

Cat. No.: HY-15476 Purity: 98.01%
Handling Instructions

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

For research use only. We do not sell to patients.

VU 0364439 Chemical Structure

VU 0364439 Chemical Structure

CAS No. : 1246086-78-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 479 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. IC50 Value: 19.8 nM(EC50) Target: mGluR in vitro: in vivo: VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).

IC50 & Target[2]

mGlu4 Receptor

19.8 nM (EC50)

Molecular Weight

422.29

Formula

C₁₈H₁₃Cl₂N₃O₃S

CAS No.

1246086-78-1

SMILES

O=C(C1=NC=CC=C1)NC2=CC=C(S(=O)(NC3=CC=CC=C3Cl)=O)C(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (118.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3680 mL 11.8402 mL 23.6804 mL
5 mM 0.4736 mL 2.3680 mL 4.7361 mL
10 mM 0.2368 mL 1.1840 mL 2.3680 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

VU 0364439VU0364439VU-0364439mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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Product Name:
VU 0364439
Cat. No.:
HY-15476
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