1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR2 Inhibitors

mGluR2 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

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Sorry. There is currently no product that acts on isoform mGluR2 together.

Please try each isoform separately.

mGluR2 Specific Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR2 mGluR8 mGluR6 mGluR7 mGluR5 mGluR4 mGluR3 mGluR1 mGluR2 Selectivity Purity
mGluR2 antagonist 1
mGluR2, IC50: 9 nM
              Selective Antagonist
JNJ-40411813
mGlu2 Receptor, EC50: 147 nM
              Selective Agonist 99.69%
JNJ-46281222
mGluR2, Kd: 1.7 nM
              Selective Inhibitor 98.79%
JNJ-42153605
mGluR2, EC50: 17 nM
              Selective Modulator 99.00%
AZD-8529
mGluR2, EC50: 285 nM
              Selective Agonist
LY2979165
mGlu2 Receptor
              Selective Agonist >98.0%
AZD-8529 mesylate
mGluR2, EC50: 285 nM
              Selective Agonist
LY3020371 hydrochloride
mGluR2, Ki: 5.3 nM
         
mGluR3, Ki: 2.5 nM
  Selective Antagonist
Biphenylindanone A
mGluR2
              Selective Agonist >99.0%
LY 541850
mGluR2, IC50: 0.161 μM
         
mGluR3, IC50: 1.05 μM
  Selective Antagonist
Eglumegad
mGluR2R, IC50: 5 nM
         
mGluR3R, IC50: 24 nM
  Pan Agonist >98.0%
LY341495
mGluR2, IC50: 21 nM
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR1a, IC50: 7.8 μM
Pan Antagonist 99.11%
L-Cysteinesulfinic acid monohydrate
mGluR2, pEC50: 3.9
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR1, pEC50: 3.92
Pan Agonist
Decoglurant
mGluR2
         
mGluR3
  Pan Modulator 99.71%
Xanthurenic acid
mGluR2
         
mGluR3
  Pan Agonist 98.17%
LY2794193
mGluR2, EC50: 47.5
mGluR2, Ki: 412
         
mGluR3, EC50: 0.47 nM
mGluR3, Ki: 0.927 nM
  Pan Agonist 99.88%
LY404039
mGluR2, Ki: 92 nM
           
mGluR1, Ki: 149 nM
Pan Inhibitor >98.0%
O-Phospho-L-serine
mGluR2
mGluR8
mGluR6
mGluR7
 
mGluR4
 
mGluR1
Pan Modulator >98.0%
L-Cysteinesulfinic acid
mGluR2, pEC50: 3.9
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR1, pEC50: 3.92
Pan Agonist
LY2812223
mGluR2, Ki: 144 nM
         
mGluR3, Ki: 156 nM
  Pan Agonist >98.0%
Pomaglumetad methionil
mGluR2
         
mGluR3
  Pan Agonist
Quisqualic acid
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
       
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
 
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
Pan Activator
DCG-IV
mGluR2R, EC50: 0.35 μM
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR1R, IC50: 389 μM
Pan Agonist
LY2140023
mGluR2
         
mGluR3
  Pan Agonist