1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR2 Inhibitors

mGluR2 Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

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Sorry. There is currently no product that acts on isoform mGluR2 together.

Please try each isoform separately.

mGluR2 Specific Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR2 mGluR1 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR2 Selectivity Purity
JNJ-40411813
mGlu2 Receptor, EC50: 147 nM
              Selective Agonist 98.97%
JNJ-42153605
mGluR2, EC50: 17 nM
              Selective Modulator 99.0%
AZD-8529
mGluR2, EC50: 285 nM
              Selective Agonist 98.43%
JNJ-46281222
mGluR2, Kd: 1.7 nM
              Selective Inhibitor 98.79%
mGluR2 antagonist 1
mGluR2, IC50: 9 nM
              Selective Antagonist 99.06%
LY2979165
mGlu2 Receptor
              Selective Agonist ≥98.0%
AZD-8529 mesylate
mGluR2, EC50: 285 nM
              Selective Agonist 99.05%
LY3020371 hydrochloride
mGluR2, Ki: 5.3 nM
 
mGluR3, Ki: 2.5 nM
          Selective Antagonist
EGLU
mGluR2, Kd: 66 μM
              Selective Antagonist
Biphenylindanone A
mGluR2
              Selective Agonist ≥99.0%
LY 541850
mGluR2, IC50: 0.161 μM
 
mGluR3, IC50: 1.05 μM
          Selective Antagonist
LY341495
mGluR2, IC50: 21 nM
mGluR1a, IC50: 7.8 μM
mGluR3, IC50: 14 nM
mGluR4, IC50: 22 μM
mGluR5a, IC50: 8.2 μM
 
mGluR7, IC50: 990 nM
mGluR8, IC50: 170 nM
Pan Antagonist 99.11%
Eglumegad
mGluR2R, IC50: 5 nM
 
mGluR3R, IC50: 24 nM
          Pan Agonist ≥98.0%
Pomaglumetad methionil hydrochloride
mGluR2
 
mGluR3
          Pan Agonist 98.20%
Xanthurenic acid
mGluR2
 
mGluR3
          Pan Agonist ≥96.0%
L-Cysteinesulfinic acid monohydrate
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
Pan Agonist 99.30%
LY404039
mGlu2 Receptor, Ki: 149 nM (Recombinant human mGluR2)
 
hmGluR3, Ki: 92 nM
          Pan Agonist ≥98.0%
LY2794193
mGluR2, EC50: 47.5
mGluR2, Ki: 412
 
mGluR3, EC50: 0.47 nM
mGluR3, Ki: 0.927 nM
          Pan Agonist 99.88%
O-Phospho-L-serine
mGluR2
mGluR1
 
mGluR4
 
mGluR6
mGluR7
mGluR8
Pan Modulator ≥98.0%
Decoglurant
mGluR2
 
mGluR3
          Pan Modulator 99.71%
L-Cysteinesulfinic acid
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
Pan Agonist
LY2812223
mGluR2, Ki: 144 nM
 
mGluR3, Ki: 156 nM
          Pan Agonist ≥98.0%
Pomaglumetad methionil
mGluR2
 
mGluR3
          Pan Agonist
Quisqualic acid
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
 
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
        Pan Activator
Oxomemazine
mGluR2, Ki: 1.65 μM
mGluR 1, Ki: 84 nM
            Pan Antagonist
DCG-IV
mGluR2R, EC50: 0.35 μM
mGluR1R, IC50: 389 μM
mGluR3R, EC50: 0.09 μM
mGluR4R, IC50: 22.5 μM
mGluR5, IC50: 630 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR8, IC50: 32 μM
Pan Agonist
LY3020371
hmGluR2, Ki: 5.26 nM
 
hmGluR3, Ki: 2.50 nM
          Pan Antagonist
VU-29
rat mGluR2, EC50: 1.5 μM
rat mGluR1, EC50: 557 nM
 
hmGluR4, EC50: 154 nM
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
      Pan Agonist 98.04%
Pomaglumetad methionil anhydrous
mGluR2
 
mGluR3
          Pan Agonist
cis-ACPD
mGluR2, EC50: 13 μM
   
mGluR4, EC50: 50 μM
        Pan Agonist