1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. AZD-8529

AZD-8529 

Cat. No.: HY-107457 Purity: 98.43%
Handling Instructions

AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

For research use only. We do not sell to patients.

AZD-8529 Chemical Structure

AZD-8529 Chemical Structure

CAS No. : 1092453-15-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 515 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

IC50 & Target[1]

mGluR2

285 nM (EC50)

In Vitro

AZD-8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM[1].
AZD-8529 does not elicit antagonist responses on mGluRs at 25 μM[1].

In Vivo

AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys[1].
AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].

Animal Model: Sprague-Dawley rats[1]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection; 2 hours before nicotine injections
Result: Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.
Clinical Trial
Molecular Weight

487.47

Formula

C₂₄H₂₄F₃N₅O₃

CAS No.

1092453-15-0

SMILES

O=C1C2=C(C)C=C(C3=NC(CN4CCNCC4)=NO3)C=C2CN1CC5=CC=C(OC(F)(F)F)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (128.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0514 mL 10.2570 mL 20.5141 mL
5 mM 0.4103 mL 2.0514 mL 4.1028 mL
10 mM 0.2051 mL 1.0257 mL 2.0514 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (12.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AZD-8529AZD8529AZD 8529mGluRMetabotropic glutamate receptorsmGluR2receptornicotineaddictiontreatmentInhibitorinhibitorinhibit

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Product Name:
AZD-8529
Cat. No.:
HY-107457
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