1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR8 Inhibitors

mGluR8 Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform mGluR8 together.

Please try each isoform separately.

mGluR8 Specific Agonists, Antagonists & Modulators
Product Name mGluR8 mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 Selectivity Purity
(RS)-PPG
hmGluR8a, EC50: 0.2 μM
     
hmGluR4a, EC50: 5.2 μM
 
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
Selective Agonist
LY341495
mGluR8, IC50: 170 nM
mGluR1a, IC50: 7.8 μM
mGluR2, IC50: 21 nM
mGluR3, IC50: 14 nM
mGluR4, IC50: 22 μM
mGluR5a, IC50: 8.2 μM
 
mGluR7, IC50: 990 nM
Pan Antagonist 99.11%
L-AP4 monohydrate
mGlu8, EC50: 0.29 μM
     
mGlu4, EC50: 0.13 μM
 
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
Pan Agonist ≥99.0%
L-Cysteinesulfinic acid monohydrate
mGluR8, pEC50: 3.94
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
  Pan Agonist 99.30%
L-AP4
mGlu8, EC50: 0.29 μM
     
mGlu4, EC50: 0.13 μM
 
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
Pan Agonist ≥99.0%
VU6005649
mGlu8 Receptor, EC50: 2.6 μM
           
mGlu7 Receptor, EC50: 0.65 μM
Pan Agonist 98.67%
O-Phospho-L-serine
mGluR8
mGluR1
mGluR2
 
mGluR4
 
mGluR6
mGluR7
Pan Modulator ≥98.0%
L-Cysteinesulfinic acid
mGluR8, pEC50: 3.94
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
  Pan Agonist
DCG-IV
mGluR8, IC50: 32 μM
mGluR1R, IC50: 389 μM
mGluR2R, EC50: 0.35 μM
mGluR3R, EC50: 0.09 μM
mGluR4R, IC50: 22.5 μM
mGluR5, IC50: 630 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
Pan Agonist