1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR8 Isoform

mGluR8

 

mGluR8 Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-70059
    LY341495
    Antagonist 99.37%
    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively.
  • HY-107982
    VU6005649
    Agonist 98.67%
    VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
  • HY-15129
    O-Phospho-L-serine
    Modulator ≥98.0%
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
  • HY-W017230
    L-Cysteinesulfinic acid monohydrate
    Agonist 99.30%
    L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
  • HY-107516
    (S)-3,4-DCPG
    Agonist ≥98.0%
    (S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC50 of 31 nM in AV12-664 cells expressing human mGluR8.
  • HY-110122
    AZ 12216052
    Modulator ≥98.0%
    AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells.
  • HY-117764
    LSP4-2022
    Agonist
    LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC50 of 0.11 μM.
  • HY-100781B
    L-AP4 monohydrate
    Agonist ≥99.0%
    L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
  • HY-100781A
    L-AP4
    Agonist 99.40%
    L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
  • HY-100804
    L-Cysteinesulfinic acid
    Agonist 99.31%
    L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
  • HY-101335
    DCG-IV
    Agonist
    DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively.
  • HY-107514
    (RS)-PPG
    Agonist
    (RS)-PPG is a potent and selective agonist for group III mGluRs.
  • HY-110190
    VU0422288
    Modulator
    VU0422288 is a positive allosteric modulator of group III mGluRs with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays.