1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR8 Inhibitors

mGluR8 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform mGluR8 together.

Please try each isoform separately.

mGluR8 Specific Agonists, Antagonists & Modulators
Product Name mGluR8 mGluR6 mGluR7 mGluR5 mGluR4 mGluR3 mGluR2 mGluR1 mGluR8 Selectivity Purity
(RS)-PPG
hmGluR8a, EC50: 0.2 μM
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
 
hmGluR4a, EC50: 5.2 μM
      Selective Agonist
LY341495
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
mGluR1a, IC50: 7.8 μM
Pan Antagonist 99.11%
L-Cysteinesulfinic acid monohydrate
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
L-APB
mGlu8, EC50: 0.29 μM
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
 
mGlu4, EC50: 0.13 μM
      Pan Agonist >99.0%
O-Phospho-L-serine
mGluR8
mGluR6
mGluR7
 
mGluR4
 
mGluR2
mGluR1
Pan Modulator >98.0%
VU6005649
mGlu8 Receptor, EC50: 2.6 μM
 
mGlu7 Receptor, EC50: 0.65 μM
          Pan Agonist 98.67%
L-Cysteinesulfinic acid
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
DCG-IV
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
mGluR1R, IC50: 389 μM
Pan Agonist