1413405-33-0
1413405-33-0
Chemical Structure
LSP4-2022
- CAS No.: 1413405-33-0
- Formula:C13H18NO8P
- Molecular Weight:347.26
IUPAC Name: (2S)-2-amino-4-(((4-(carboxymethoxy)phenyl)(hydroxy)methyl)(hydroxy)phosphoryl)butanoic acid
InChIKey: BGOFVWMHMQISHB-NKUHCKNESA-N
SMILES: OC([C@@H](N)CCP(C(C1=CC=C(C=C1)OCC(O)=O)O)(O)=O)=O
Biological Activity: LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC50 of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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LSP4-2022 | 98.06% | LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC50 of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity. | ||||||||||||||||||||
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References
- [1]. Goudet C, et al. A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93. [Content Brief]
- [2]. Podkowa K, Rzeźniczek S, Marciniak M, Acher F, Pilc A, Pałucha-Poniewiera A. A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action. Neuropharmacology. 2015 Oct;97:338-45. [Content Brief]
