1290628-31-7
1290628-31-7
Chemical Structure
AZ 12216052
- CAS No.: 1290628-31-7
- Formula:C19H22BrNOS
- Molecular Weight:392.35
IUPAC Name: 2-((4-bromobenzyl)thio)-N-(4-(sec-butyl)phenyl)acetamide
InChIKey: QKUYZJOTWYRWNF-UHFFFAOYSA-N
SMILES: O=C(CSCC1=CC=C(C=C1)Br)NC2=CC=C(C(CC)C)C=C2
Biological Activity: AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect[1][2][3][4].
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AZ 12216052 | 98.73% | AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect. | ||||||||||||||||||||
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References
- [1]. Reed BT, et al. Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds. Neuropharmacology. 2013 Apr;67:88-94. [Content Brief]
- [2]. Jantas D, et al. Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):443-451. [Content Brief]
- [3]. Duvoisin RM, et al. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010 Oct 15;212(2):168-73. [Content Brief]
- [4]. Duvoisin RM, et al. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav Brain Res. 2011 Aug 1;221(1):50-4. [Content Brief]
