23052-81-5
23052-81-5
Chemical Structure
L-AP4
Synonym(s): L-APB
- CAS No.: 23052-81-5
- Formula:C4H10NO5P
- Molecular Weight:183.10
IUPAC Name: (S)-2-amino-4-phosphonobutanoic acid
InChIKey: DDOQBQRIEWHWBT-VKHMYHEASA-N
SMILES: O=C(O)[C@@H](N)CCP(O)(O)=O
Biological Activity: L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-AP4 | 99.01% | L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. | ||||||||||||||||||||
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References
- [1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [Content Brief]
- [2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6. [Content Brief]
Keywords
