1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. L-AP3

L-AP3 (Synonyms: 3-Phosphono-L-alanine)

Cat. No.: HY-108546
Handling Instructions

L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively.

For research use only. We do not sell to patients.

L-AP3 Chemical Structure

L-AP3 Chemical Structure

CAS No. : 23052-80-4

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Description

L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1].

In Vitro

L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively[1].
L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1].
L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM)[1].
L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

169.07

Formula

C₃H₈NO₅P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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L-AP3
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