1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR4 Inhibitors

mGluR4 Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform mGluR4 together.

Please try each isoform separately.

mGluR4 Specific Agonists, Antagonists, Activators & Modulators
Product Name mGluR4 mGluR1 mGluR2 mGluR3 mGluR5 mGluR6 mGluR7 mGluR8 mGluR4 Selectivity Purity
(1R,2S)-VU0155041
mGluR4
              Selective Agonist ≥98.0%
Foliglurax monohydrochloride
mGlu4, EC50: 79 nM
              Selective Agonist 98.93%
Lu AF21934
mGlu4 Receptor, EC50: 500 nM
              Selective Agonist 99.27%
ADX88178
mGluR4, EC50: 4 nM
              Selective Agonist 99.60%
VU0364770
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
     
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
    Selective Agonist 99.57%
VU0361737
Human mGlu4, EC50: 240 nM
Rat mGlu4, EC50: 110 nM
              Selective Agonist 99.83%
TCN238
mGlu4 Receptor, EC50: 1 μM
              Selective Modulator 98.31%
VU 0364439
mGlu4 Receptor, EC50: 19.8 nM
              Selective Agonist 98.01%
VU6001376
mGlu4, EC50: 50.1 nM
              Selective
Foliglurax
mGlu4, EC50: 79 nM
              Selective Agonist
VU0155041
Human mGlu4, EC50: 798 nM
Rat mGlu4, EC50: 693 nM
              Selective Agonist
VU0364770 hydrochloride
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
     
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
    Selective Agonist 99.82%
VU0155041 sodium
mGluR4, EC50: 693 nM
              Selective Agonist
Cinnabarinic acid
mGluR4
              Selective Agonist
LY341495
mGluR4, IC50: 22 μM
mGluR1a, IC50: 7.8 μM
mGluR2, IC50: 21 nM
mGluR3, IC50: 14 nM
mGluR5a, IC50: 8.2 μM
 
mGluR7, IC50: 990 nM
mGluR8, IC50: 170 nM
Pan Antagonist 99.11%
L-Cysteinesulfinic acid monohydrate
mGluR4, pEC50: 2.7
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
Pan Agonist 99.30%
L-APB
mGlu4, EC50: 0.13 μM
       
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
mGlu8, EC50: 0.29 μM
Pan Agonist ≥99.0%
O-Phospho-L-serine
mGluR4
mGluR1
mGluR2
   
mGluR6
mGluR7
mGluR8
Pan Modulator ≥98.0%
L-Cysteinesulfinic acid
mGluR4, pEC50: 2.7
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
Pan Agonist
Quisqualic acid
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
          Pan Activator
DCG-IV
mGluR4R, IC50: 22.5 μM
mGluR1R, IC50: 389 μM
mGluR2R, EC50: 0.35 μM
mGluR3R, EC50: 0.09 μM
mGluR5, IC50: 630 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR8, IC50: 32 μM
Pan Agonist
(RS)-PPG
hmGluR4a, EC50: 5.2 μM
       
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
hmGluR8a, EC50: 0.2 μM
Pan Agonist
VU-29
hmGluR4, EC50: 154 nM
rat mGluR1, EC50: 557 nM
rat mGluR2, EC50: 1.5 μM
 
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
      Pan Agonist 98.04%
cis-ACPD
mGluR4, EC50: 50 μM
 
mGluR2, EC50: 13 μM
          Pan Agonist