1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR4 Inhibitors

mGluR4 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform mGluR4 together.

Please try each isoform separately.

mGluR4 Specific Agonists, Antagonists, Activators & Modulators
Product Name mGluR4 mGluR8 mGluR6 mGluR7 mGluR5 mGluR3 mGluR2 mGluR1 mGluR4 Selectivity Purity
Lu AF21934
mGlu4 Receptor, EC50: 500 nM
              Selective Agonist 99.27%
ADX88178
mGluR4, EC50: 4 nM
              Selective Agonist 99.60%
Foliglurax monohydrochloride
mGlu4, EC50: 79 nM
              Selective Agonist 98.93%
VU0364770
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
 
mGlu6, EC50: 6.8 μM
 
mGlu5, EC50: 17.9 μM
      Selective Agonist 99.57%
PHCCC
mGluR4, EC50: 6 μM
              Selective Antagonist 99.96%
VU0361737
Human mGlu4, EC50: 240 nM
Rat mGlu4, EC50: 110 nM
              Selective Agonist 99.83%
TCN238
mGlu4 Receptor, EC50: 1 μM
              Selective Modulator 98.31%
VU 0364439
mGlu4 Receptor, EC50: 19.8 nM
              Selective Agonist 98.01%
VU6001376
mGlu4, EC50: 50.1 nM
              Selective
(1R,2S)-VU0155041
mGluR4
              Selective Agonist >98.0%
Foliglurax
mGlu4, EC50: 79 nM
              Selective Agonist
VU0364770 hydrochloride
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
 
mGlu6, EC50: 6.8 μM
 
mGlu5, EC50: 17.9 μM
      Selective Agonist 99.82%
LY341495
mGluR4, IC50: 22 μM
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
mGluR1a, IC50: 7.8 μM
Pan Antagonist 99.11%
L-Cysteinesulfinic acid monohydrate
mGluR4, pEC50: 2.7
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
L-APB
mGlu4, EC50: 0.13 μM
mGlu8, EC50: 0.29 μM
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
        Pan Agonist >99.0%
O-Phospho-L-serine
mGluR4
mGluR8
mGluR6
mGluR7
   
mGluR2
mGluR1
Pan Modulator >98.0%
L-Cysteinesulfinic acid
mGluR4, pEC50: 2.7
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
Quisqualic acid
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
         
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
Pan Activator
DCG-IV
mGluR4R, IC50: 22.5 μM
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
mGluR1R, IC50: 389 μM
Pan Agonist
(RS)-PPG
hmGluR4a, EC50: 5.2 μM
hmGluR8a, EC50: 0.2 μM
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
        Pan Agonist