1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU0155041

VU0155041 

Cat. No.: HY-14417
Handling Instructions

VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).

For research use only. We do not sell to patients.

VU0155041 Chemical Structure

VU0155041 Chemical Structure

CAS No. : 1093757-42-6

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Description

VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)[1].

IC50 & Target[1]

Human mGlu4

798 nM (EC50)

Rat mGlu4

693 nM (EC50)

In Vitro

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
Dosage: 31 nmol, 93 nmol (10 μL)
Administration: Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours
Result: Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.
Molecular Weight

316.18

Formula

C₁₄H₁₅Cl₂NO₃

CAS No.

1093757-42-6

SMILES

O=C([[email protected]](CCCC1)[[email protected]]1C(O)=O)NC2=CC(Cl)=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

VU0155041VU 0155041VU-0155041mGluRMetabotropic glutamate receptorsmGluR4partial glutamateInhibitorinhibitorinhibit

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VU0155041
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HY-14417
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