1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU0155041 sodium

VU0155041 sodium 

Cat. No.: HY-14417B
Handling Instructions

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).

For research use only. We do not sell to patients.

VU0155041 sodium Chemical Structure

VU0155041 sodium Chemical Structure

CAS No. : 1259372-69-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of VU0155041 sodium:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)[1].

IC50 & Target[1]

mGluR4

693 nM (EC50)

In Vitro

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
Dosage: 31, 93 nmol
Administration: I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
Result: Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
Molecular Weight

338.16

Formula

C₁₄H₁₄Cl₂NNaO₃

CAS No.

1259372-69-4

SMILES

O=C([[email protected]](CCCC1)[[email protected]]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

VU0155041VU 0155041VU-0155041mGluRMetabotropic glutamate receptorsmGluR4partial glutamateInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
VU0155041 sodium
Cat. No.:
HY-14417B
Quantity:
MCE Japan Authorized Agent: