VU0155041 sodium
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1259372-69-4
- Fòrmula: C14H14Cl2NNaO3
- Peso molecular:338.16
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
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HY-W015546
β-N-methylamino-L-alanine hydrochlorideNeurotoxin -
HY-W015546R
β-N-methylamino-L-alanine hydrochloride (Standard)Neurotoxin -
HY-110122
AZ 12216052mGluR8 PAM -
HY-103575
MFZ 10-7mGluR5 Antagonist -
HY-13058
ADX-47273mGluR5 PAM -
HY-100407
JNJ16259685mGlu1 Receptor Antagonist -
HY-14569
CDPPBmGluR5 Modulator -
HY-103111
MMPIP hydrochloridemGluR7 Antagonist -
HY-110146
XAP044mGlu7 Antagonist -
HY-101333
CPPGGroup II/III mGluR Antagonist -
HY-14419
TCN238mGlu4 Receptor PAM -
HY-100605
VU0483605mGlu1 Modulator
Actividad biológica
Descripciòn
IC50 & Target
[1]|
mGluR4 693 nM (EC50) |
In Vitro
VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
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Dosage:31, 93 nmol
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Administration:I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
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Result:Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
Chemical Information
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No. CAS 1259372-69-4
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Peso molecular 338.16
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Fòrmula C14H14Cl2NNaO3
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SMILES
O=C([C@H](CCCC1)[C@H]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU0155041 sodium Related Classifications
HY-14417B Related Classifications
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