VU0155041 sodium
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 1259372-69-4
- Formula: C14H14Cl2NNaO3
- Molecular Weight:338.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mGluR4 693 nM (EC50) |
VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
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Dosage:31, 93 nmol
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Administration:I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
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Result:Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
Chemical Information
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CAS No. 1259372-69-4
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Molecular Weight 338.16
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Formula C14H14Cl2NNaO3
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SMILES
O=C([C@H](CCCC1)[C@H]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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