52809-07-1
52809-07-1
Chemical Structure
Quisqualic acid
Synonym(s): L-Quisqualic acid
- CAS No.: 52809-07-1
- Formula:C5H7N3O5
- Molecular Weight:189.13
IUPAC Name: (S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
InChIKey: ASNFTDCKZKHJSW-REOHCLBHSA-N
SMILES: O=C(O)[C@@H](N)CN(C(N1)=O)OC1=O
Biological Activity: Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2].
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Quisqualic acid | 98.0% | Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica. | ||||||||||||||||||||
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References
- [1]. Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [Content Brief]
- [2]. H Bräuner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. [Content Brief]
