(-)-Aspartic acid (Synonyms: (R)-Aspartic acid; D-(-)-Aspartic acid)

Name: (-)-Aspartic acid
Brand: MedChemExpress
SKU: HY-42068
Rating: 4.5 (1 reviews)

Cat. No.: HY-42068 Pureza: 98.0%: Ficha de datos
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(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system.

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(-)-Aspartic acid Estructura química

No. CAS : 1783-96-6

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
500 mg	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
50 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtener un presupuesto

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Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Aspartic acid:

(-)-Aspartic acid-d₃ Obtener un presupuesto
(-)-Aspartic acid (Standard) Obtener un presupuesto

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	> 1000 μM Compound: (R)-1	Agonistic activity at mGlu1-alpha receptor expressed in CHO cells Agonistic activity at mGlu1-alpha receptor expressed in CHO cells	[PMID: 8759641]
CHO	EC₅₀	> 1000 μM Compound: (R)-1	Agonistic activity at mGlu2 receptor expressed in CHO cells Agonistic activity at mGlu2 receptor expressed in CHO cells	[PMID: 8759641]
CHO	EC₅₀	> 1000 μM Compound: (R)-1	Agonistic activity at mGlu6 receptor expressed in CHO cells Agonistic activity at mGlu6 receptor expressed in CHO cells	[PMID: 8759641]
HEK293	EC₅₀	398 μM Compound: D-asp	Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862) Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862)	[PMID: 35677430]

In Vitro

(-)-Aspartic acid (1, 10, 30 mM) inhibits HGF cell pyroptosis through the TLRs-NLRP3-caspase 1-GSDMD pathway to prevent gingival fibroblast inflammation^[1].
(-)-Aspartic acid (0.1, 1, 10 nM, 48 h) stimulates steroid production in mammalian Leydig cell lines by regulating LH receptor (LHR) exposure on the cell membrane^[2].
(-)-Aspartic acid acts as a neuropeptide co transmitter by releasing glutamate or GABA as its main neurotransmitter pathway ^[5].
(-)-Aspartic acidactivates cAMP dependent gene transcription, inhibits CREB function, reduces BDNF expression, and induces excitotoxic neuronal death^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1].

Cell Line:	Human gingival fibroblasts (HGFs)
Concentration:	1, 10, 30 mM
Incubation Time:
Result:	Inhibited the expression of NLRP3, caspase-1, GSDMD, IL-1 β, and IL-18 genes

Western Blot Analysis^[2].

Cell Line:	MA-10 cell
Concentration:	0.1, 1, 10 nM
Incubation Time:	48 h
Result:	Increased the expression level of steroidogenic acute regulatory (StAR) protein with hCG

In Vivo

(-)-Aspartic acid (0.5, 1, 2, 4 μmol/g; i.p.) participates in the synthesis of testosterone in rats^[3].
(-)-Aspartic acid (2 μmol/g; i.p.) increases the secretion of gonadotropin-releasing hormone (GnRH), prolactin (PRL), luteinizing hormone (LH), and growth hormone (GH) in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male rats^[3].
Dosage:	0.5, 1, 2, 4 μmol/g
Administration:	Intraperitoneal injection (i.p.)
Result:	Increased production of LH, testosterone, and progesterone in the blood.

Animal Model:	85-day-old male rats^[4].
Dosage:	2.0 μmol/g
Administration:	Intraperitoneal injection (i.p.)
Result:	Increased levels of gonadotropin-releasing hormone (GnRH), prolactin (PRL), luteinizing hormone (LH), and growth hormone (GH) in rats.

Peso molecular

133.10

Fòrmula

C₄H₇NO₄

No. CAS

1783-96-6

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(O)=O)CC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

H₂O : 66.67 mg/mL (500.90 mM; ultrasonic and adjust pH to 7 with 1M NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5131 mL	37.5657 mL	75.1315 mL
5 mM	1.5026 mL	7.5131 mL	15.0263 mL
10 mM	0.7513 mL	3.7566 mL	7.5131 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (15.03 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.0%

Select Batch:

Ficha de datos (278 KB) SDS (396 KB)

COA (248 KB) HNMR (235 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Xuechun Du, et al. D-aspartic acid protects against gingival fbroblasts infammation by suppressing pyroptosis. Mol Biol Rep. 2022 Jul;49(7):5821-5829. [Content Brief]

[2]. Di Nisio A, et al. D-Aspartic acid stimulates steroidogenesis through the delay of LH receptor internalization in a mammalian Leydig cell line. J Endocrinol Invest. 2016 Feb;39(2):207-213. [Content Brief]

[3]. D'Aniello A, et al. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci. 1996;59(2):97-104. [Content Brief]

[4]. D'Aniello A, et al. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 2000 Apr;14(5):699-714. [Content Brief]

[5]. D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.5131 mL	37.5657 mL	75.1315 mL	187.8287 mL
	5 mM	1.5026 mL	7.5131 mL	15.0263 mL	37.5657 mL
	10 mM	0.7513 mL	3.7566 mL	7.5131 mL	18.7829 mL
	15 mM	0.5009 mL	2.5044 mL	5.0088 mL	12.5219 mL
	20 mM	0.3757 mL	1.8783 mL	3.7566 mL	9.3914 mL
	25 mM	0.3005 mL	1.5026 mL	3.0053 mL	7.5131 mL
	30 mM	0.2504 mL	1.2522 mL	2.5044 mL	6.2610 mL
	40 mM	0.1878 mL	0.9391 mL	1.8783 mL	4.6957 mL
	50 mM	0.1503 mL	0.7513 mL	1.5026 mL	3.7566 mL
	60 mM	0.1252 mL	0.6261 mL	1.2522 mL	3.1305 mL
	80 mM	0.0939 mL	0.4696 mL	0.9391 mL	2.3479 mL
	100 mM	0.0751 mL	0.3757 mL	0.7513 mL	1.8783 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(-)-Aspartic acid Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Aspartic acid1783-96-6(R)-Aspartic acidD-(-)-Aspartic acidPyroptosisendogenous amino acidsneurological developmentendocrine systemInhibitorinhibitorinhibit

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(-)-Aspartic acid (Synonyms: (R)-Aspartic acid; D-(-)-Aspartic acid)

Revisión del cliente

Other Forms of (-)-Aspartic acid:

(-)-Aspartic acid Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

(-)-Aspartic acid Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

(-)-Aspartic acid Related Classifications

Keywords:

Productos vistos recientemente:

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