(S)-Willardiine
Based on 1 Customer Validation
(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system.
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- 純度: 98.93%
- CAS 番号: 21416-43-3
- 分子式: C7H9N3O4
- 分子量:199.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
iGluR アイソフォーム固有の製品をすべて表示
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生物活性
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AMPA Receptor |
Kainate Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
11.5 μM
Compound: (S)-2a, (S)-willardiine
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Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
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[PMID: 18811139] |
(S)-Willardiine (10-12-10-3 M; 60 min) binds with low affinity to homomeric hGluR1, hGluR2, and hGluR4 receptors, displaying the weakest potency among tested willardiine analogs on these human AMPA receptor subtypes[1].
(S)-Willardiine (10-12-10-3 M; 60 min) binds with very low affinity to homomeric hGluR5 receptors, displaying the weakest potency among tested willardiine analogs on this human kainate receptor subtype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 21416-43-3
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性状 Solid
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分子量 199.17
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分子式 C7H9N3O4
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Color White to off-white
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SMILES
N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
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別名
(-)-Willardiine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
H2O : < 0.1 mg/mL (insoluble)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(S)-Willardiine 関連分類
HY-12499 関連分類
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