1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. (S)-Willardiine

(S)-Willardiine (Synonyms: (-)-Willardiine)

Cat. No.: HY-12499 Purity: 98.70%
Handling Instructions

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.

For research use only. We do not sell to patients.

(S)-Willardiine Chemical Structure

(S)-Willardiine Chemical Structure

CAS No. : 21416-43-3

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50 mg USD 414 In-stock
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Description

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. IC50 value: 44.8 uM(EC50) [1] Target: AMPA/kainate receptor agonist in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2]. in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].

Molecular Weight

199.16

Formula

C₇H₉N₃O₄

CAS No.

21416-43-3

SMILES

N[[email protected]@H](CN(C(N1)=O)C=CC1=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

References

Purity: 98.70%

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Keywords:

(S)-Willardiine(-)-WillardiineiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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