21416-43-3
Chemical Structure
(S)-Willardiine
Synonym(s): (-)-Willardiine
- CAS No.: 21416-43-3
- Formula:C7H9N3O4
- Molecular Weight:199.17
IUPAC Name: (S)-2-amino-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid
InChIKey: FACUYWPMDKTVFU-BYPYZUCNSA-N
SMILES: N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
Biological Activity: (S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system[1].
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(S)-Willardiine | 98.93% | (S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system. | ||||||||||||||||||||
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Keywords