1161205-04-4
1161205-04-4
Chemical Structure
VU0361737
Synonym(s): ML-128
- CAS No.: 1161205-04-4
- Formula:C13H11ClN2O2
- Molecular Weight:262.69
IUPAC Name: N-(4-chloro-3-methoxyphenyl)picolinamide
InChIKey: ARYUXFNGXHNNDM-UHFFFAOYSA-N
SMILES: ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O
Biological Activity: VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0361737 | 99.65% | VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research. | ||||||||||||||||||||
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References
- [1]. Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8. [Content Brief]
- [2]. Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. J Med Chem. 2011 Feb 24;54(4):1106-10. [Content Brief]
Keywords
