1. GPCR/G Protein
  2. mGluR

VU0361737 (Synonyms: ML-128)

Cat. No.: HY-14418 Purity: 99.37%
Handling Instructions

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.

For research use only. We do not sell to patients.

VU0361737 Chemical Structure

VU0361737 Chemical Structure

CAS No. : 1161205-04-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 468 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. IC50 value: 110 nM (EC50, for rat ), 240 nM (EC50, for human) Target: mGlu4 in vitro: VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. [3] in vivo: VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). [3]

References
Molecular Weight

262.69

Formula

C₁₃H₁₁ClN₂O₂

CAS No.

1161205-04-4

SMILES

ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 43 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
VU0361737
Cat. No.:
HY-14418
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