1. GPCR/G Protein
  2. mGluR

VU0361737 (Synonyms: ML-128)

Cat. No.: HY-14418 Purity: 99.37%
Handling Instructions

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.

For research use only. We do not sell to patients.

VU0361737 Chemical Structure

VU0361737 Chemical Structure

CAS No. : 1161205-04-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Estimated Time of Arrival: December 31
100 mg USD 468 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. IC50 value: 110 nM (EC50, for rat ), 240 nM (EC50, for human) Target: mGlu4 in vitro: VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. [3] in vivo: VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). [3]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 43 mg/mL (163.69 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8068 mL 19.0338 mL 38.0677 mL
5 mM 0.7614 mL 3.8068 mL 7.6135 mL
10 mM 0.3807 mL 1.9034 mL 3.8068 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

262.69

Formula

C₁₃H₁₁ClN₂O₂

CAS No.

1161205-04-4

SMILES

ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
VU0361737
Cat. No.:
HY-14418
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VU0361737

Cat. No.: HY-14418