1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU0361737

VU0361737 (Synonyms: ML-128)

Cat. No.: HY-14418 Purity: 99.83%
Handling Instructions

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat receptors, respectively. VU0361737 (ML-128) has neuroprotective effect. VU0361737 (ML-128) has the potential for Parkinson's disease research.

For research use only. We do not sell to patients.

VU0361737 Chemical Structure

VU0361737 Chemical Structure

CAS No. : 1161205-04-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
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100 mg USD 468 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat receptors, respectively. VU0361737 (ML-128) has neuroprotective effect. VU0361737 (ML-128) has the potential for Parkinson's disease research[1][2].

IC50 & Target[2]

Human mGlu4

240 nM (EC50)

Rat mGlu4

110 nM (EC50)

In Vitro

VU0361737 displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors[1].
VU0361737 (1-10 μM) partially attenuating the staurosporine- and doxorubicin-evoked cell death on human neuroblastoma SH-SY5Y cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0361737 (10mg/kg; i.p.) shows high clearance and low plasma exposure in rats, with a plasma T1/2 of 1.9 hours[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (225-250 g)[1]
Dosage: 10mg/kg (Pharmacokinetic Analysis)
Administration: Intraperitoneal injection
Result: T1/2=1.9 hours.
Molecular Weight

262.69

Formula

C₁₃H₁₁ClN₂O₂

CAS No.

1161205-04-4

SMILES

ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (380.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8068 mL 19.0338 mL 38.0677 mL
5 mM 0.7614 mL 3.8068 mL 7.6135 mL
10 mM 0.3807 mL 1.9034 mL 3.8068 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VU0361737ML-128VU 0361737VU-0361737ML128ML 128mGluRMetabotropic glutamate receptorsneuroprotectiveParkinson'sdiseaseInhibitorinhibitorinhibit

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Product Name:
VU0361737
Cat. No.:
HY-14418
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