1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Foliglurax monohydrochloride

Foliglurax monohydrochloride (Synonyms: PXT002331 (monohydrochloride))

Cat. No.: HY-108703A Purity: 98.93%
Handling Instructions

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. Antiparkinsonian effect.

For research use only. We do not sell to patients.

Foliglurax monohydrochloride Chemical Structure

Foliglurax monohydrochloride Chemical Structure

CAS No. : 2133294-96-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Foliglurax monohydrochloride:

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Description

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

IC50 & Target[1]

mGlu4

79 nM (EC50)

In Vitro

Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].

Clinical Trial
Molecular Weight

457.97

Formula

C₂₃H₂₄ClN₃O₃S

CAS No.

2133294-96-7

SMILES

O/N=C1C=C(C2=CC3=C(C=CS3)C=N2)OC4=CC=C(CCCN5CCOCC5)C=C\14.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1835 mL 10.9177 mL 21.8355 mL
5 mM 0.4367 mL 2.1835 mL 4.3671 mL
10 mM 0.2184 mL 1.0918 mL 2.1835 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Foliglurax monohydrochloride
Cat. No.:
HY-108703A
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