1. GPCR/G Protein
  2. mGluR
  3. Foliglurax

Foliglurax (Synonyms: PXT002331)

Cat. No.: HY-108703
Handling Instructions

Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM. Antiparkinsonian effect.

For research use only. We do not sell to patients.

Foliglurax Chemical Structure

Foliglurax Chemical Structure

CAS No. : 1883329-51-8

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  • Technical Information

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  • References

Description

Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

IC50 & Target[1]

mGlu4

79 nM (EC50)

In Vitro

Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (12.34 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3724 mL 11.8621 mL 23.7242 mL
5 mM 0.4745 mL 2.3724 mL 4.7448 mL
10 mM 0.2372 mL 1.1862 mL 2.3724 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.52 mg/mL (1.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.52 mg/mL (1.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

421.51

Formula

C₂₃H₂₃N₃O₃S

CAS No.

1883329-51-8

SMILES

O/N=C1C=C(C2=CC3=C(C=CS3)C=N2)OC4=CC=C(CCCN5CCOCC5)C=C\14

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Foliglurax
Cat. No.:
HY-108703
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Foliglurax

Cat. No.: HY-108703