2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. Foliglurax

Foliglurax  (Synonyms: PXT002331)

Cat. No.: HY-108703
Handling Instructions

Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM. Antiparkinsonian effect.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Foliglurax monohydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Foliglurax Chemical Structure

Foliglurax Chemical Structure

CAS No. : 1883329-51-8

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Foliglurax:

Other Forms of Foliglurax:

Foliglurax Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

IC50 & Target[1]

mGlu4

79 nM (EC50)

In Vitro

Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Foliglurax Related Antibodies
Clinical Trial
Molecular Weight

421.51

Formula

C23H23N3O3S
CAS No.
SMILES

O/N=C1C=C(C2=CC3=C(C=CS3)C=N2)OC4=CC=C(CCCN5CCOCC5)C=C\14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (12.34 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3724 mL 11.8621 mL 23.7242 mL
5 mM 0.4745 mL 2.3724 mL 4.7448 mL
10 mM 0.2372 mL 1.1862 mL 2.3724 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.52 mg/mL (1.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.52 mg/mL (1.23 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Foliglurax Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Foliglurax1883329-51-8PXT002331PXT 002331PXT-002331mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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