1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mGluR
    Endogenous Metabolite
  3. L-Cysteinesulfinic acid

L-Cysteinesulfinic acid 

Cat. No.: HY-100804
Handling Instructions

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

For research use only. We do not sell to patients.

L-Cysteinesulfinic acid Chemical Structure

L-Cysteinesulfinic acid Chemical Structure

CAS No. : 1115-65-7

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Description

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].

Molecular Weight

153.16

Formula

C₃H₇NO₄S

CAS No.

1115-65-7

SMILES

N[[email protected]@H](CS(O)=O)C(O)=O

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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L-Cysteinesulfinic acid
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HY-100804
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