L-Cysteinesulfinic acid
Based on 2 publication(s) in Google Scholar
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 1115-65-7
- Formula: C3H7NO4S
- Molecular Weight:153.16
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Cysteinesulfinic acid
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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mGluR1 3.92 (pEC50) |
mGluR2 3.9 (pEC50) |
mGluR4 2.7 (pEC50) |
mGluR5 4.6 (pEC50) |
mGluR6 4.0 (pEC50) |
mGluR8 3.94 (pEC50) |
Human Endogenous Metabolite |
L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1115-65-7
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Appearance Solid
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Molecular Weight 153.16
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Formula C3H7NO4S
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Color White to off-white
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SMILES
N[C@@H](CS(O)=O)C(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
H2O : 100 mg/mL (652.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [Content Brief]
[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.5291 mL | 32.6456 mL | 65.2912 mL | 163.2280 mL |
| 5 mM | 1.3058 mL | 6.5291 mL | 13.0582 mL | 32.6456 mL | |
| 10 mM | 0.6529 mL | 3.2646 mL | 6.5291 mL | 16.3228 mL | |
| 15 mM | 0.4353 mL | 2.1764 mL | 4.3527 mL | 10.8819 mL | |
| 20 mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 8.1614 mL | |
| 25 mM | 0.2612 mL | 1.3058 mL | 2.6116 mL | 6.5291 mL | |
| 30 mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 5.4409 mL | |
| 40 mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 4.0807 mL | |
| 50 mM | 0.1306 mL | 0.6529 mL | 1.3058 mL | 3.2646 mL | |
| 60 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
| 80 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 100 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Cysteinesulfinic acid Related Classifications
HY-100804 Related Classifications
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