L-Cysteinesulfinic acid

Cat. No.: HY-100804 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

For research use only. We do not sell to patients.

L-Cysteinesulfinic acid Chemical Structure

CAS No. : 1115-65-7

Size	Price	Stock	Quantity
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of L-Cysteinesulfinic acid:

L-Cysteinesulfinic acid monohydrate In-stock

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Biological Activity
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Description

IC₅₀ & Target

pEC50: 3.92±0.03 (mGluR1), 4.6±0.2 (mGluR5), 3.9±0.2 (mGluR2), 2.7±0.2 (mGluR4), 4.0±0.2 (mGluR6), and 3.94±0.08 (mGluR8)^[1]

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC₅₀ of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

153.16

Formula

C₃H₇NO₄S

CAS No.

1115-65-7

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (816.14 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5291 mL	32.6456 mL	65.2912 mL
5 mM	1.3058 mL	6.5291 mL	13.0582 mL
10 mM	0.6529 mL	3.2646 mL	6.5291 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (245 KB) SDS (0 KB)

COA (246 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.5291 mL	32.6456 mL	65.2912 mL	163.2280 mL
	5 mM	1.3058 mL	6.5291 mL	13.0582 mL	32.6456 mL
	10 mM	0.6529 mL	3.2646 mL	6.5291 mL	16.3228 mL
	15 mM	0.4353 mL	2.1764 mL	4.3527 mL	10.8819 mL
	20 mM	0.3265 mL	1.6323 mL	3.2646 mL	8.1614 mL
	25 mM	0.2612 mL	1.3058 mL	2.6116 mL	6.5291 mL
	30 mM	0.2176 mL	1.0882 mL	2.1764 mL	5.4409 mL
	40 mM	0.1632 mL	0.8161 mL	1.6323 mL	4.0807 mL
	50 mM	0.1306 mL	0.6529 mL	1.3058 mL	3.2646 mL
	60 mM	0.1088 mL	0.5441 mL	1.0882 mL	2.7205 mL
	80 mM	0.0816 mL	0.4081 mL	0.8161 mL	2.0403 mL
	100 mM	0.0653 mL	0.3265 mL	0.6529 mL	1.6323 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cysteinesulfinic acid1115-65-7Inhibitorinhibitorinhibit

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L-Cysteinesulfinic acid

Other Forms of L-Cysteinesulfinic acid: