L-Cysteinesulfinic acid monohydrate

Name: L-Cysteinesulfinic acid monohydrate
Brand: MedChemExpress
SKU: HY-W017230
Rating: 4.5 (1 reviews)

Cat. No.: HY-W017230 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

For research use only. We do not sell to patients.

L-Cysteinesulfinic acid monohydrate Chemical Structure

CAS No. : 207121-48-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 98	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Cysteinesulfinic acid monohydrate:

L-Cysteinesulfinic acid In-stock

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View All mGluR Isoform Specific Products:

View All Isoforms

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

mGluR1

3.92 (pEC₅₀)

mGluR2

3.9 (pEC₅₀)

mGluR4

2.7 (pEC₅₀)

mGluR5

4.6 (pEC₅₀)

mGluR6

4.0 (pEC₅₀)

mGluR8

3.94 (pEC₅₀)

Human Endogenous Metabolite

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC₅₀ of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.17

Formula

C₃H₉NO₅S

CAS No.

207121-48-0

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS(O)=O)C(O)=O.O

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 41.67 mg/mL (243.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8421 mL	29.2107 mL	58.4215 mL
5 mM	1.1684 mL	5.8421 mL	11.6843 mL
10 mM	0.5842 mL	2.9211 mL	5.8421 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (273 KB) SDS (392 KB)

COA (249 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [Content Brief]

[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.8421 mL	29.2107 mL	58.4215 mL	146.0536 mL
	5 mM	1.1684 mL	5.8421 mL	11.6843 mL	29.2107 mL
	10 mM	0.5842 mL	2.9211 mL	5.8421 mL	14.6054 mL
	15 mM	0.3895 mL	1.9474 mL	3.8948 mL	9.7369 mL
	20 mM	0.2921 mL	1.4605 mL	2.9211 mL	7.3027 mL
	25 mM	0.2337 mL	1.1684 mL	2.3369 mL	5.8421 mL
	30 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	40 mM	0.1461 mL	0.7303 mL	1.4605 mL	3.6513 mL
	50 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9211 mL
	60 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	80 mM	0.0730 mL	0.3651 mL	0.7303 mL	1.8257 mL
	100 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.