L-Cysteinesulfinic acid monohydrate

Name: L-Cysteinesulfinic acid monohydrate
Brand: MedChemExpress
SKU: HY-W017230
Rating: 5.0 (2 reviews)

Cat. No.: HY-W017230 Purity: 99.81%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

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L-Cysteinesulfinic acid monohydrate 화학구조

CAS No. : 207121-48-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of L-Cysteinesulfinic acid monohydrate:

L-Cysteinesulfinic acid In-stock
L-Cysteinesulfinic acid monohydrate (Standard) 견적 받기

2 Publications Citing Use of MCE L-Cysteinesulfinic acid monohydrate

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mGluR Isoform Specific Products:

View All Isoforms

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

mGluR1

3.92 (pEC₅₀)

mGluR2

3.9 (pEC₅₀)

mGluR4

2.7 (pEC₅₀)

mGluR5

4.6 (pEC₅₀)

mGluR6

4.0 (pEC₅₀)

mGluR8

3.94 (pEC₅₀)

Human Endogenous Metabolite

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC₅₀ of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

171.17

화학식

C₃H₉NO₅S

CAS No.

207121-48-0

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS(O)=O)C(O)=O.O

Structure Classification

Others

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 41.67 mg/mL (243.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8421 mL	29.2107 mL	58.4215 mL
5 mM	1.1684 mL	5.8421 mL	11.6843 mL
10 mM	0.5842 mL	2.9211 mL	5.8421 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.81%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (249 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [Content Brief]

[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.8421 mL	29.2107 mL	58.4215 mL	146.0536 mL
	5 mM	1.1684 mL	5.8421 mL	11.6843 mL	29.2107 mL
	10 mM	0.5842 mL	2.9211 mL	5.8421 mL	14.6054 mL
	15 mM	0.3895 mL	1.9474 mL	3.8948 mL	9.7369 mL
	20 mM	0.2921 mL	1.4605 mL	2.9211 mL	7.3027 mL
	25 mM	0.2337 mL	1.1684 mL	2.3369 mL	5.8421 mL
	30 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	40 mM	0.1461 mL	0.7303 mL	1.4605 mL	3.6513 mL
	50 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9211 mL
	60 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	80 mM	0.0730 mL	0.3651 mL	0.7303 mL	1.8257 mL
	100 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.