1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. L-Cysteinesulfinic acid monohydrate

L-Cysteinesulfinic acid monohydrate 

Cat. No.: HY-W017230 Purity: 99.30%
Handling Instructions

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

For research use only. We do not sell to patients.

L-Cysteinesulfinic acid monohydrate Chemical Structure

L-Cysteinesulfinic acid monohydrate Chemical Structure

CAS No. : 207121-48-0

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Solution
10 mM * 1 mL in Water USD 132 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 200 In-stock
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100 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-Cysteinesulfinic acid monohydrate:

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Description

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

IC50 & Target

mGluR1

3.92 (pEC50)

mGluR2

3.9 (pEC50)

mGluR4

2.7 (pEC50)

mGluR5

4.6 (pEC50)

mGluR6

4.0 (pEC50)

mGluR8

3.94 (pEC50)

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.17

Formula

C₃H₉NO₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (730.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8421 mL 29.2107 mL 58.4215 mL
5 mM 1.1684 mL 5.8421 mL 11.6843 mL
10 mM 0.5842 mL 2.9211 mL 5.8421 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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L-Cysteinesulfinic acid monohydrate
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