L-Cysteinesulfinic acid monohydrate
Based on 2 publication(s) in Google Scholar
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 207121-48-0
- Formula: C3H9NO5S
- Molecular Weight:171.17
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Cysteinesulfinic acid monohydrate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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mGluR1 3.92 (pEC50) |
mGluR2 3.9 (pEC50) |
mGluR4 2.7 (pEC50) |
mGluR5 4.6 (pEC50) |
mGluR6 4.0 (pEC50) |
mGluR8 3.94 (pEC50) |
Human Endogenous Metabolite |
L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 207121-48-0
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Appearance Solid
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Molecular Weight 171.17
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Formula C3H9NO5S
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Color White to off-white
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SMILES
N[C@@H](CS(O)=O)C(O)=O.O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
H2O : 41.67 mg/mL (243.44 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [Content Brief]
[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.8421 mL | 29.2107 mL | 58.4215 mL | 146.0536 mL |
| 5 mM | 1.1684 mL | 5.8421 mL | 11.6843 mL | 29.2107 mL | |
| 10 mM | 0.5842 mL | 2.9211 mL | 5.8421 mL | 14.6054 mL | |
| 15 mM | 0.3895 mL | 1.9474 mL | 3.8948 mL | 9.7369 mL | |
| 20 mM | 0.2921 mL | 1.4605 mL | 2.9211 mL | 7.3027 mL | |
| 25 mM | 0.2337 mL | 1.1684 mL | 2.3369 mL | 5.8421 mL | |
| 30 mM | 0.1947 mL | 0.9737 mL | 1.9474 mL | 4.8685 mL | |
| 40 mM | 0.1461 mL | 0.7303 mL | 1.4605 mL | 3.6513 mL | |
| 50 mM | 0.1168 mL | 0.5842 mL | 1.1684 mL | 2.9211 mL | |
| 60 mM | 0.0974 mL | 0.4868 mL | 0.9737 mL | 2.4342 mL | |
| 80 mM | 0.0730 mL | 0.3651 mL | 0.7303 mL | 1.8257 mL | |
| 100 mM | 0.0584 mL | 0.2921 mL | 0.5842 mL | 1.4605 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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