1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. (RS)-PPG

(RS)-PPG 

Cat. No.: HY-107514
Handling Instructions

(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity.

For research use only. We do not sell to patients.

(RS)-PPG Chemical Structure

(RS)-PPG Chemical Structure

CAS No. : 120667-15-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

IC50 & Target[1]

hmGluR8a

0.2 μM (EC50)

hmGluR6

4.7 μM (EC50)

hmGluR4a

5.2 μM (EC50)

hmGluR7b

185 μM (EC50)

In Vitro

Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].

Molecular Weight

231.14

Formula

C₈H₁₀NO₅P

CAS No.

120667-15-4

SMILES

O=C(O)C(N)C1=CC=C(P(O)(O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(RS)-PPGmGluRMetabotropic glutamate receptorshmGluR4ahmGluR6hmGluR7bhmGluR8aAnticonvulsiveneuroprotectiveInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
(RS)-PPG
Cat. No.:
HY-107514
Quantity:
MCE Japan Authorized Agent: