(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4. doi: 10.1016/s0960-894x(00)00197-9.
F Gasparini  1 ,  W Inderbitzin ,  E Francotte ,  G Lecis ,  P Richert ,  Z Dragic ,  R Kuhn ,  P J Flor
Affiliations
PMID: 10866390 DOI: 10.1016/s0960-894x(00)00197-9
Abstract

A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III Metabotropic Glutamate Receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.