1623101-11-0
1623101-11-0
Chemical Structure
VU0483605
- No. CAS: 1623101-11-0
- Formula:C20H10Cl3N3O3
- Molecular Weight:446.67
IUPAC Name: 3-chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
InChIKey: HJQXPBKPTGWZCF-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2
Biological Activity: VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively[1].
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VU0483605 | 97.30% | VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively. | ||||||||||||||||||||
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