Art. -Nr.: HY-70059

LY341495

Name: LY341495
Brand: MedChemExpress
SKU: HY-70059
Price: 45.00 USD
Availability: InStock
Rating: 5 (15 reviews)

15 Cited Publications

Kundenbewertung

Based on 15 publication(s) in Google Scholar

LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC₅₀s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.30%
CAS. Nr.: 201943-63-7
Formel: C₂₀H₁₉NO₅
Molecular Weight:353.37

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

LY341495 Chemical Structure

CAS. Nr.: 201943-63-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Publications (15)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[5]

mGluR1a

7.8 μM (IC₅₀)

mGluR2

21 nM (IC₅₀)

mGluR3

14 nM (IC₅₀)

mGluR4

22 μM (IC₅₀)

mGluR5a

8.2 μM (IC₅₀)

mGluR7

990 nM (IC₅₀)

mGluR8

170 nM (IC₅₀)

Alle mGluR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.2 μM Compound: 7	Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2 Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2	[PMID: 11720869]
CHO	EC₅₀	>100000 nM Compound: 9	Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: 9	Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: 9	Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: 9	Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	1140 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	11400 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	14.2 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	23.2 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	2650 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	8990 nM Compound: 9	Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: 9	Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	2.9 nM Compound: 1, LY-341495	Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells	[PMID: 18348906]
HEK293	IC₅₀	0.016 μM Compound: 7	Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cells Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cells	[PMID: 11720869]

In Vivo

LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats^[1]. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268^[2]. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 201943-63-7
Appearance Solid
Molecular Weight 353.37
Formel C₂₀H₁₉NO₅
Color White to off-white
SMILES

O=C(O)[C@@H]1[C@H](C1)[C@@](N)(CC2C3=C(C=CC=C3)OC4=C2C=CC=C4)C(O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (15)

All In Vivo Efficacy StudyWBIHCIF

Sort by:

Journal Impact Factor

Nature

Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. [Abstract]

2024 Jul;631(8022):826-834. PMID: 38987597
Cell Res

Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity. [Abstract]

2025 Mar;35(3):165-185. PMID: 39875551

LY341495 purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Mar;35(3):165-185. [Abstract]

Representative western blot and quantification of AKT signal in GT1-7 cells treated with 10 ng/ml Raptin and GRM3 agonists (LY354740, LY2794193, LY379268), inhibitors (LY341495) or allosteric agents (VU0650786).
Cell Res

Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. [Abstract]

2023 Oct;33(10):762-774. PMID: 37286794
Sci China Life Sci

Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells. [Abstract]

2025 Feb;68(2):502-514. PMID: 39428428
Neuropsychopharmacology

A rat model of volitional mutual social interactions. [Abstract]

2025 Oct;50(11):1643-1654. PMID: 40281038
CNS Neurosci Ther

Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease. [Abstract]

2026 May;32(5):e70916. PMID: 42138018
Pain

N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. [Abstract]

2016 Aug;157(8):1711-1723. PMID: 27075430

LY341495 purchased from MedChemExpress. Usage Cited in: Pain. 2016 Aug;157(8):1711-1723. [Abstract]

LY341495 and Sulfasalazine mildly suppress the effects of chronic constrictive injury (CCI)-induced mechanical allodynia and matrix metalloproteinase-9 activity by N-acetyl-cysteine (NAC).
Front Pharmacol

LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. [Abstract]

2020 Feb 28:11:183. PMID: 32180729

LY341495 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Feb 28:11:183. [Abstract]

LY341495 (1 mg/kg; IP; 30 min prior to MPTP injection (30 mg/kg/d) once a day for 7 days consecutively) significantly decreased compared with the normal + saline group and a significant longer time-down (TLA) was spent by the MPTP + saline group and MPTP + LY341495 group compared with the normal + saline group (both p < 0.01) and LY354740 + saline group (both p < 0.05).

LY341495 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Feb 28:11:183. [Abstract]

LY341495 (1 mg/kg; IP; for four times (30 min before each MPTP injection); once a day for 6 days consecutively) showed that latency times in acute MPTP-mice treated with LY341495 (1 mg/kg) significantly decreased, both MPTP + saline group and MPTP + LY341495 group exhibited longer times (Turn) than normal + saline group and MPTP + LY354740 (4 mg/kg) group.

LY341495 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Feb 28:11:183. [Abstract]

(A, B) Immunohistochemical images and corresponding TH positive cell counts in SN from each group.LY341495 (1 mg/kg; IP; 30 min prior to MPTP injection (30 mg/kg/d) once a day for 7 days consecutively) counted fewer TH-positive cells in sub-acute MPTP-mice treated.

LY341495 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Feb 28:11:183. [Abstract]

LY341495 (1 mg/kg; IP; 30 min prior to MPTP injection (30 mg/kg/d) once a day for 7 days consecutively) exhibited much higher expressions of p-Fyn Tyr416.

LY341495 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Feb 28:11:183. [Abstract]

LY341495 (1 mg/kg; IP; 30 min prior to MPTP injection (30 mg/kg/d) once a day for 7 days consecutively) showed an elevation of the number of PLK2 positive cells, indicating increased expression of PLK2. Immunofluorescence of PLK2 positive cell counts in SN.
Aquaculture and Fisheries

2023 Aug 19.
Neuropharmacology

The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation. [Abstract]

2020 Oct 15:177:108231. PMID: 32693006
Neuropharmacology

The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity. [Abstract]

2018 May 1:133:354-365. PMID: 29407217
Phytopathol Res

(2019) 1:12.
University of Maryland

2025.
bioRxiv

2024 November 03.
biorxiv

2024 May 26.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 6 mg/mL (16.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8299 mL

14.1495 mL

28.2990 mL

5 mM

0.5660 mL

2.8299 mL

5.6598 mL

10 mM

0.2830 mL

1.4149 mL

2.8299 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.6 mg/mL (1.70 mM); Clear solution

This protocol yields a clear solution of ≥ 0.6 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Animal Administration^[1]

The rats are randomLy divided into six experimental groups (10 rats per group): vehicle and 0.05, 0.1, 0.3, 1, and 3 mg/kg LY341495. The LY341495 doses are selected on the basis of results from previous Published studies that evaluated the effects of this compound on cognition. The rats are subjected to a training session that consisted of two 2-min trials. The animals receive either vehicle or LY341495 immediately after T1. Using the 2-min trial duration, an ITI of 1 h is used because recognition memory is still intact in untreated control rats under these experimental conditions

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pitsikas N, et al. The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats. Behav Brain Res. 2012 May 1;230(2):374-9. [Content Brief]

[2]. Sutton LP, et al. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.J Neurochem. 2011 Jun;117(6):973-83. [Content Brief]

[3]. Linden AM, et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology. 2009 Aug;57(2):172-82. Epub 2009 May 27. [Content Brief]

[4]. Li J, et al. N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. Pain. 2016 Aug;157(8):1711-23. [Content Brief]

[5]. A E Kingston, et al. LY341495 Is a Nanomolar Potent and Selective Antagonist of Group II Metabotropic Glutamate Receptors.Neuropharmacology. 1998;37(1):1-12. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8299 mL	14.1495 mL	28.2990 mL	70.7474 mL
	5 mM	0.5660 mL	2.8299 mL	5.6598 mL	14.1495 mL
	10 mM	0.2830 mL	1.4149 mL	2.8299 mL	7.0747 mL
	15 mM	0.1887 mL	0.9433 mL	1.8866 mL	4.7165 mL

Bioz

Keywords

LY341495

15 Cited Publications

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LY341495

Publications Citing Use of MedChemExpress (MCE) LY341495

Alle mGluR Isoform-spezifische Produkte anzeigen