1. GPCR/G Protein
  2. mGluR

LY341495 

Cat. No.: HY-70059
Handling Instructions

LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.

For research use only. We do not sell to patients.
LY341495 Chemical Structure

LY341495 Chemical Structure

CAS No. : 201943-63-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $117 In-stock
2 mg $99 In-stock
5 mg $150 In-stock
10 mg $220 In-stock
25 mg $500 Get quote
50 mg   Get quote  
100 mg   Get quote  

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    LY341495 purchased from MCE. Usage Cited in: Pain. 2016 Aug;157(8):1711-23.

    LY341495 and Sulfasalazine mildly suppress the effects of chronic constrictive injury (CCI)-induced mechanical allodynia and matrix metalloproteinase-9 activity by N-acetyl-cysteine (NAC).
    • Biological Activity

    • Protocol

    • Technical Information

    • References

    Description

    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.

    IC50 & Target

    IC50: 2.9 nM (mGluR-2, human), 10 nM (mGluR-3, human), 170 nM (mGluR-8, human)

    In Vivo

    LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats[1]. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268[2]. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice[3]

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.8299 mL 14.1495 mL 28.2990 mL
    5 mM 0.5660 mL 2.8299 mL 5.6598 mL
    10 mM 0.2830 mL 1.4149 mL 2.8299 mL
    Please refer to the solubility information to select the appropriate solvent.
    Animal Administration
    [1]

    LY341495 is dissolved in 0.1mol/LNaOH to a final volume of 5 mL, with saline (0.9% NaCl) solution.

    The rats are randomLy divided into six experimental groups (10 rats per group): vehicle and 0.05, 0.1, 0.3, 1, and 3 mg/kg LY341495. The LY341495 doses are selected on the basis of results from previous Published studies that evaluated the effects of this compound on cognition. The rats are subjected to a training session that consisted of two 2-min trials. The animals receive either vehicle or LY341495 immediately after T1. Using the 2-min trial duration, an ITI of 1 h is used because recognition memory is still intact in untreated control rats under these experimental conditions  MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    353.37

    Formula

    C₂₀H₁₉NO₅

    CAS No.

    201943-63-7

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    LY341495
    Cat. No.:
    HY-70059
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