2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. L-AP4

L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

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L-AP4 Chemical Structure

L-AP4 Chemical Structure

CAS No. : 23052-81-5

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Other Forms of L-AP4:

L-AP4 Related Antibodies

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Description

L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

IC50 & Target

mGlu4

0.13 μM (EC50)

mGlu8

0.29 μM (EC50)

mGlu6

1.0 μM (EC50)

mGlu7

249 μM (EC50)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats.[2]
Dosage: 5-30 μg.
Administration: Intrathecal inhection 4-5 days.
Result: Dose-dependently increased paw withdrawal threshold.
Molecular Weight

183.10

Formula

C4H10NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (273.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4615 mL 27.3075 mL 54.6150 mL
5 mM 1.0923 mL 5.4615 mL 10.9230 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (246 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4615 mL 27.3075 mL 54.6150 mL 136.5374 mL
5 mM 1.0923 mL 5.4615 mL 10.9230 mL 27.3075 mL
10 mM 0.5461 mL 2.7307 mL 5.4615 mL 13.6537 mL
15 mM 0.3641 mL 1.8205 mL 3.6410 mL 9.1025 mL
20 mM 0.2731 mL 1.3654 mL 2.7307 mL 6.8269 mL
25 mM 0.2185 mL 1.0923 mL 2.1846 mL 5.4615 mL
30 mM 0.1820 mL 0.9102 mL 1.8205 mL 4.5512 mL
40 mM 0.1365 mL 0.6827 mL 1.3654 mL 3.4134 mL
50 mM 0.1092 mL 0.5461 mL 1.0923 mL 2.7307 mL
60 mM 0.0910 mL 0.4551 mL 0.9102 mL 2.2756 mL
80 mM 0.0683 mL 0.3413 mL 0.6827 mL 1.7067 mL
100 mM 0.0546 mL 0.2731 mL 0.5461 mL 1.3654 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-AP4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-AP423052-81-5L-APBmGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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