1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. L-AP4

L-AP4 (Synonyms: L-APB)

Cat. No.: HY-100781A Purity: 99.40%
Handling Instructions

L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

For research use only. We do not sell to patients.

L-AP4 Chemical Structure

L-AP4 Chemical Structure

CAS No. : 23052-81-5

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5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

IC50 & Target

mGlu4

0.13 μM (EC50)

mGlu8

0.29 μM (EC50)

mGlu6

1.0 μM (EC50)

mGlu7

249 μM (EC50)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats.[2]
Dosage: 5-30 μg.
Administration: Intrathecal inhection 4-5 days.
Result: Dose-dependently increased paw withdrawal threshold.
Molecular Weight

183.10

Formula

C₄H₁₀NO₅P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (273.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4615 mL 27.3075 mL 54.6150 mL
5 mM 1.0923 mL 5.4615 mL 10.9230 mL
10 mM 0.5461 mL 2.7307 mL 5.4615 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.40%

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L-AP4
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HY-100781A
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