1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. mGluR
    Apoptosis
  3. Cinnabarinic acid

Cinnabarinic acid 

Cat. No.: HY-W011417
Handling Instructions

Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway. Cinnabarinic acid induces cell apoptosis.

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Cinnabarinic acid Chemical Structure

Cinnabarinic acid Chemical Structure

CAS No. : 606-59-7

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Description

Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway. Cinnabarinic acid induces cell apoptosis[1].

IC50 & Target[1]

mGluR4

 

In Vitro

Cinnabarinic acid (0-100 μM) does not activate mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, and mGlu8 receptors as shown by measurements of [3H]InsP formation. In contrast, cinnabarinic acid acts as a partial agonist of mGlu4 receptors by increasing [3H]InsP formation by approximately 35% at 100 μM, which is 5-fold less efficacious than ACPT-I in activating mGlu4 receptors in HEK293 cells transiently transfected with rat mGlu1, -2, -4, -5, -6, -7, or -8 receptors[1].
Cinnabarinic acid (0-100 μM) reduces cAMP formation in a concentration-dependent manner with an excellent potency and efficacy. At 30 μM, cinnabarinic acid is effective at 30 μM, and substantially inhibits cAMP formation in cultured cerebellar granule cells[1].

Molecular Weight

300.22

Formula

C₁₄H₈N₂O₆

CAS No.

606-59-7

SMILES

O=C(C1=C(N)C(C=C2OC3=C(N=C21)C(C(O)=O)=CC=C3)=O)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cinnabarinic acidmGluRApoptosisMetabotropic glutamate receptorsAntipsychotic-Likekynurenineorthosteric agonistmetabolitePrefrontal CortexInhibitorinhibitorinhibit

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Cinnabarinic acid
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