1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR4 Isoform
  5. mGluR4 Modulator

mGluR4 Modulator

mGluR4 Modulators (6):

Cat. No. Product Name Effect Purity
  • HY-15129
    O-Phospho-L-serine
    Modulator ≥98.0%
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
  • HY-14419
    TCN238
    Modulator 98.31%
    TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC50 of 1 μM.
  • HY-110190
    VU0422288
    Modulator
    VU0422288 is a positive allosteric modulator of group III mGluRs with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays.
  • HY-119078
    VU0080241
    Modulator 99.47%
    VU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM.
  • HY-100605
    VU0483605
    Modulator
    VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM).
  • HY-144698
    mGlu4 receptor agonist 1
    Modulator
    mGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC50 of 308 nM.