1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. DCG-IV

DCG-IV 

Cat. No.: HY-101335
Handling Instructions

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

For research use only. We do not sell to patients.

DCG-IV Chemical Structure

DCG-IV Chemical Structure

CAS No. : 147782-19-2

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Description

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

In Vitro

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

In Vivo

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage: 10, 5, or 1 mg/kg
Administration: I.p.
Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
Molecular Weight

203.15

Formula

C₇H₉NO₆

CAS No.

147782-19-2

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DCG-IVmGluRMetabotropic glutamate receptorsanticonvulsiveneuroprotective neurotoxicity locomotion behavioralchangesInhibitorinhibitorinhibit

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