1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. DCG-IV

DCG-IV 

Cat. No.: HY-101335
Handling Instructions

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

For research use only. We do not sell to patients.

DCG-IV Chemical Structure

DCG-IV Chemical Structure

CAS No. : 147782-19-2

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Description

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

IC50 & Target[1]

mGluR2R

0.35 μM (EC50)

mGluR3R

0.09 μM (EC50)

mGluR1R

389 μM (IC50)

mGluR5

630 μM (IC50)

mGluR4R

22.5 μM (IC50)

mGluR6

39.6 μM (IC50)

mGluR7

40.1 μM (IC50)

mGluR8

32 μM (IC50)

In Vitro

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

In Vivo

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage: 10, 5, or 1 mg/kg
Administration: I.p.
Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
Molecular Weight

203.15

Formula

C₇H₉NO₆

CAS No.

147782-19-2

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DCG-IVmGluRMetabotropic glutamate receptorsanticonvulsiveneuroprotective neurotoxicity locomotion behavioralchangesInhibitorinhibitorinhibit

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