CPPG  (Synonyms: (RS)-CPPG)

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC₅₀=2.2 nM) over group II (IC₅₀=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors^[1].

CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC₅₀=2.2 nM)- and L-CCG-I (IC₅₀=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

271.21

C₁₁H₁₄NO₅P

183364-82-1

O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2

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• [1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.  [Content Brief]