1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. CPPG

CPPG (Synonyms: (RS)-CPPG)

Cat. No.: HY-101333
Handling Instructions

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.

For research use only. We do not sell to patients.

CPPG Chemical Structure

CPPG Chemical Structure

CAS No. : 183364-82-1

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Description

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

IC50 & Target[1]

group III mGlu receptors

2.2 nM (IC50)

group II mGlu receptors

46.2 nM (IC50)

In Vitro

CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].

Molecular Weight

271.21

Formula

C₁₁H₁₄NO₅P

CAS No.

183364-82-1

SMILES

O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CPPG(RS)-CPPGmGluRMetabotropic glutamate receptorsratcortexAMPaccumulationselectiveCNScerebralInhibitorinhibitorinhibit

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