VU0360172 hydrochloride
Based on 1 Customer Validation
VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 1309976-62-2
- Formula: C18H16ClFN2O
- Molecular Weight:330.78
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mGluR5 16 nM (EC50) |
mGluR5 195 nM (Ki) |
Chemical Information
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CAS No. 1309976-62-2
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Appearance Solid
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Molecular Weight 330.78
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Formula C18H16ClFN2O
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Color White to off-white
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SMILES
O=C(C1=CN=C(C=C1)C#CC2=CC(F)=CC=C2)NC3CCC3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (75.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0232 mL | 15.1158 mL | 30.2316 mL | 75.5789 mL |
| 5 mM | 0.6046 mL | 3.0232 mL | 6.0463 mL | 15.1158 mL | |
| 10 mM | 0.3023 mL | 1.5116 mL | 3.0232 mL | 7.5579 mL | |
| 15 mM | 0.2015 mL | 1.0077 mL | 2.0154 mL | 5.0386 mL | |
| 20 mM | 0.1512 mL | 0.7558 mL | 1.5116 mL | 3.7789 mL | |
| 25 mM | 0.1209 mL | 0.6046 mL | 1.2093 mL | 3.0232 mL | |
| 30 mM | 0.1008 mL | 0.5039 mL | 1.0077 mL | 2.5193 mL | |
| 40 mM | 0.0756 mL | 0.3779 mL | 0.7558 mL | 1.8895 mL | |
| 50 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5116 mL | |
| 60 mM | 0.0504 mL | 0.2519 mL | 0.5039 mL | 1.2596 mL |
VU0360172 hydrochloride Related Classifications
HY-107504 Related Classifications
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