2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. YM-298198 hydrochloride

YM-298198 hydrochloride 

Cat. No.: HY-103568 Purity: 99.61%
COA Handling Instructions

YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.

For research use only. We do not sell to patients.

YM-298198 hydrochloride Chemical Structure

YM-298198 hydrochloride Chemical Structure

CAS No. : 1216398-09-2

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10 mg USD 190 In-stock
25 mg USD 420 In-stock
50 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

YM-298198 hydrochloride Related Antibodies

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Description

YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders[1].

IC50 & Target[1]

mGluR 1

 

In Vitro

YM-298198 hydrochloride shows a high affinity for mGluR1 with a Ki of 19 nM for rat mGluR1-NIH membranes[1].
YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells, with an IC50 of 16 nM[1].
YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YM-298198 hydrochloride Related Antibodies
In Vivo

YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice[1]
Dosage: 30 mg/kg
Administration: Oral administration
Result: Prolonged nociceptive response latency in streptozotocin (200 mg/kg)-induced hyperalgesic mice.
Molecular Weight

378.92

Appearance

Solid

Formula

C18H23ClN4OS
CAS No.
SMILES

O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)N(C4CCCCC4)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (329.88 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6391 mL 13.1954 mL 26.3908 mL
5 mM 0.5278 mL 2.6391 mL 5.2782 mL
10 mM 0.2639 mL 1.3195 mL 2.6391 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.49 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.61%

COA (249 KB) HNMR (321 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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YM-298198 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

YM-2981981216398-09-2YM298198YM 298198mGluRMetabotropic glutamate receptorsneurologicaldisordersneurotransmissionmetabotropicglutamatereceptorInhibitorinhibitorinhibit

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