1309976-62-2
1309976-62-2
Chemical Structure
VU0360172 hydrochloride
- CAS No.: 1309976-62-2
- Formula:C18H16ClFN2O
- Molecular Weight:330.78
IUPAC Name: N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide hydrochloride
InChIKey: NBGAPTWZQXSEAA-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C=C1)C#CC2=CC(F)=CC=C2)NC3CCC3.Cl
Biological Activity: VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
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VU0360172 hydrochloride | 98.94% | VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice. | ||||||||||||||||||||
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References
- [1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. [Content Brief]
Keywords
