1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. EGLU

EGLU (Synonyms: (2S)-α-Ethylglutamic acid; (2S)-α-EGLU)

Cat. No.: HY-101332
Handling Instructions

EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent.

For research use only. We do not sell to patients.

EGLU Chemical Structure

EGLU Chemical Structure

CAS No. : 170984-72-2

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Description

EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent[1].

IC50 & Target

mGluR2

66 μM (Kd)

In Vitro

EGLU (200 μM) selectively antagonizes (lS,3S)-ACPD-induced depressions of the monosynaptic component of the DRVRP, displaying little or no antagonist activity versus L-AP6 induced depressions or on the DRVRP alone[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

175.18

Formula

C₇H₁₃NO₄

CAS No.

170984-72-2

SMILES

N[[email protected]](CCC(O)=O)(CC)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EGLU(2S)-α-Ethylglutamic acid (2S)-α-EGLUmGluRMetabotropic glutamate receptorsantidepressant(lS,3S)-ACPD,DRVRP,monosynapticInhibitorinhibitorinhibit

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EGLU
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