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DL-AP4 (Synonyms: 2-Amino-4-phosphonobutyric acid)

Cat. No.: HY-100743
Handling Instructions

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system.

For research use only. We do not sell to patients.

DL-AP4 Chemical Structure

DL-AP4 Chemical Structure

CAS No. : 6323-99-5

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Description

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].

IC50 & Target

Glutamate[1]

In Vitro

DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells[1].
DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane[2].
DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM[3].
DL-AP4 (50 µM; 0-2 seconds) blocks the light response of a series of 10 ms 405-nm flashes, at the following strengths: 3, 10, 30, 100, 300, 990, 3000, 9900 photons μm-2[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

183.10

Formula

C4H10NO5P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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DL-AP4
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