6323-99-5
6323-99-5
Chemical Structure
DL-AP4
Synonym(s): 2-Amino-4-phosphonobutyric acid
- CAS No.: 6323-99-5
- Formula:C4H10NO5P
- Molecular Weight:183.10
IUPAC Name: 2-amino-4-phosphonobutanoic acid
InChIKey: DDOQBQRIEWHWBT-UHFFFAOYSA-N
SMILES: O=C(O)C(N)CCP(O)(O)=O
Biological Activity: DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].
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DL-AP4 | 98.0% | DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system. | ||||||||||||||||||||
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DL-AP4 (Standard) | ≥98% | DL-AP4 (Standard) is the analytical standard of DL-AP4. This product is intended for research and analytical applications. DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system. | ||||||||||||||||||||
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References
- [1]. Cull-Candy SG, et al. 2-Amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle. Nature. 1976 Jul 29;262(5567):408-9. [Content Brief]
- [2]. Yamashita M, et al. Responses of rod bipolar cells isolated from the rat retina to the glutamate agonist 2-amino-4-phosphonobutyric acid (APB). J Neurosci. 1991 Aug;11(8):2372-82. [Content Brief]
- [3]. Crooks SL, et al. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J Med Chem. 1986 Oct;29(10):1988-95. [Content Brief]
